Junya Tominaga1, Tae Iwasawa2, Makiko Murota3, Hiroaki Arakawa4, Takeshi Johkoh5, Yasuhiko Yamano6, Yoshiaki Zaizen7, Kazuya Ichikado8, Mikiko Hashisako9, Yasuhiro Kondoh6, Kensuke Kataoka6, Masaki Okamoto10, Kiminori Fujimoto11, Junya Fukuoka7. 1. Department of Diagnostic Radiology, Tohoku University School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, 9808574, Japan. jrtomi@jf6.so-net.ne.jp. 2. Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan. 3. Department of Radiology, Faculty of Medicine, Kagawa University, Miki, Japan. 4. Department of Radiology, Dokkyo Medical University, Mibu, Japan. 5. Department of Diagnostic Radiology, Kansai Rosai Hospital, Amagasaki, Japan. 6. Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Japan. 7. Department of Pathology, Nagasaki University School of Medicine, Nagasaki, Japan. 8. Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan. 9. Department of Anatomic Pathology, Pathological Sciences , Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan. 10. Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan. 11. Department of Radiology and Center for Diagnostic Imaging, Kurume University School of Medicine, Kurume, Japan.
Abstract
PURPOSE: To evaluate computed tomography (CT) findings of nonspecific interstitial pneumonia (NSIP) based on the current classification of idiopathic interstitial pneumonias (IIPs) and elucidate a characteristic of previously diagnosed NSIP excluded from the current classification. MATERIALS AND METHODS: The study included 74 patients with biopsy-proven NSIP (idiopathic NSIP [I-NSIP], 39 patients; NSIP associated with connective tissue disease [CTD-NSIP], 35 patients). Among patients who were compatible with the current classification of IIPs, 29 and 21 were categorized as having current I-NSIP and current CTD-NSIP, respectively. The remaining 24 patients were categorized as having previous I-NSIP or previous CTD-NSIP due to the primary pathologic diagnosis of cellular NSIP or associated findings of acute inflammatory changes. CT findings were evaluated and compared among the four groups. RESULTS: Current I-NSIP was indicated by ground-glass attenuation and reticulation with traction bronchiectasis/bronchiolectasis in predominantly peribronchovascular areas of the lower lung zone. The previous I-NSIP group tended to show broader airspace consolidation than the current I-NSIP group (p = 0.068). The previous CTD-NSIP group showed significantly broader airspace consolidation than the current I-NSIP group (p = 0.035). CONCLUSION: Broad airspace consolidation is a characteristic of previously diagnosed CTD-NSIP excluded from the current classification of IIPs.
PURPOSE: To evaluate computed tomography (CT) findings of nonspecific interstitial pneumonia (NSIP) based on the current classification of idiopathic interstitial pneumonias (IIPs) and elucidate a characteristic of previously diagnosed NSIP excluded from the current classification. MATERIALS AND METHODS: The study included 74 patients with biopsy-proven NSIP (idiopathic NSIP [I-NSIP], 39 patients; NSIP associated with connective tissue disease [CTD-NSIP], 35 patients). Among patients who were compatible with the current classification of IIPs, 29 and 21 were categorized as having current I-NSIP and current CTD-NSIP, respectively. The remaining 24 patients were categorized as having previous I-NSIP or previous CTD-NSIP due to the primary pathologic diagnosis of cellular NSIP or associated findings of acute inflammatory changes. CT findings were evaluated and compared among the four groups. RESULTS: Current I-NSIP was indicated by ground-glass attenuation and reticulation with traction bronchiectasis/bronchiolectasis in predominantly peribronchovascular areas of the lower lung zone. The previous I-NSIP group tended to show broader airspace consolidation than the current I-NSIP group (p = 0.068). The previous CTD-NSIP group showed significantly broader airspace consolidation than the current I-NSIP group (p = 0.035). CONCLUSION: Broad airspace consolidation is a characteristic of previously diagnosed CTD-NSIP excluded from the current classification of IIPs.
Authors: C Bnà; M Zompatori; V Poletti; E Spaggiari; A Chetta; E Calabrò; F Ormitti; E Berti; A Cancellieri; M Chilosi Journal: Radiol Med Date: 2005 May-Jun Impact factor: 3.469