Literature DB >> 32871847

Raloxifene and Bazedoxifene Could Be Promising Candidates for Preventing the COVID-19 Related Cytokine Storm, ARDS and Mortality.

Karel Smetana1,2, Daniel Rosel2,3, Jan BrÁbek4,3.   

Abstract

The FDA-approved drugs raloxifene and bazedoxifene could be among the best candidates to prevent mortality in severe COVID-19 patients. Raloxifene and bazedoxifene inhibit IL-6 signaling at therapeutic doses, suggesting they have the potential to prevent the cytokine storm, ARDS and mortality in severe COVID-19 patients, as is being shown with humanized antibodies blocking IL-6 signaling. In addition, raloxifene and bazedoxifene are selective estrogen receptor modulators with strong antiviral activity. Copyright
© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Entities:  

Keywords:  COVID-19 therapy; IL6; SARS-CoV-2; bazedoxifene; cytokine storm; lung failure; raloxifene

Mesh：

Substances：

Year:  2020        PMID： 32871847      PMCID： PMC7652447          DOI： 10.21873/invivo.12135

Source DB:  PubMed          Journal:  In Vivo        ISSN： 0258-851X            Impact factor:   2.155


  7 in total

1.  Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface.

Authors:  Huameng Li; Hui Xiao; Li Lin; David Jou; Vandana Kumari; Jiayuh Lin; Chenglong Li
Journal:  J Med Chem       Date:  2014-01-31       Impact factor: 7.446

2.  Cytokine release syndrome in severe COVID-19.

Authors:  John B Moore; Carl H June
Journal:  Science       Date:  2020-04-17       Impact factor: 47.728

Review 3.  Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications.

Authors:  Karel Smetana; Jan Brábek
Journal:  In Vivo       Date:  2020-06       Impact factor: 2.155

4.  Selective oestrogen receptor modulators lasofoxifene and bazedoxifene inhibit joint inflammation and osteoporosis in ovariectomised mice with collagen-induced arthritis.

Authors:  Annica Andersson; Angelina I Bernardi; Alexandra Stubelius; Merja Nurkkala-Karlsson; Claes Ohlsson; Hans Carlsten; Ulrika Islander
Journal:  Rheumatology (Oxford)       Date:  2015-09-30       Impact factor: 7.580

5.  Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs.

Authors:  Sangeun Jeon; Meehyun Ko; Jihye Lee; Inhee Choi; Soo Young Byun; Soonju Park; David Shum; Seungtaek Kim
Journal:  Antimicrob Agents Chemother       Date:  2020-06-23       Impact factor: 5.191

6.  Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Authors:  Pathum Thilakasiri; Jennifer Huynh; Ashleigh R Poh; Chin Wee Tan; Tracy L Nero; Kelly Tran; Adam C Parslow; Shoukat Afshar-Sterle; David Baloyan; Natalie J Hannan; Michael Buchert; Andrew Mark Scott; Michael Dw Griffin; Frederic Hollande; Michael W Parker; Tracy L Putoczki; Matthias Ernst; Ashwini L Chand
Journal:  EMBO Mol Med       Date:  2019-04       Impact factor: 12.137

7.  Bazedoxifene exhibits growth suppressive activity by targeting interleukin-6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma.

Authors:  Haiyan Ma; Dan Yan; Yina Wang; Wei Shi; Tianshu Liu; Chongqiang Zhao; Shengqi Huo; Jialin Duan; Jingwen Tao; Maocai Zhai; Pengcheng Luo; Junyi Guo; Lei Tian; Lulu Mageta; David Jou; Cuntai Zhang; Chenglong Li; Jiayuh Lin; Jiagao Lv; Sheng Li; Li Lin
Journal:  Cancer Sci       Date:  2019-02-16       Impact factor: 6.716
  7 in total
  17 in total

Review 1.  Pediatric Inflammatory Multisystem Syndrome (PIMS) - Potential role for cytokines such Is IL-6.

Authors:  L Lacina; J Brábek; Š Fingerhutová; J Zeman; K Smetana
Journal:  Physiol Res       Date:  2021-04-30       Impact factor: 1.881

Review 2.  Science's Response to CoVID-19.

Authors:  Marcus J C Long; Yimon Aye
Journal:  ChemMedChem       Date:  2021-06-22       Impact factor: 3.540

3.  Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa.

Authors:  Tania Aguado; Marta García; Adela García; Gemma Ferrer-Mayorga; Lucía Martínez-Santamaría; Marcela Del Río; Luisa-María Botella; José-María Sánchez-Puelles
Journal:  Cells       Date:  2020-09-16       Impact factor: 6.600

Review 4.  Raloxifene as a treatment option for viral infections.

Authors:  Subin Hong; JuOae Chang; Kwiwan Jeong; Wonsik Lee
Journal:  J Microbiol       Date:  2021-02-01       Impact factor: 3.422

5.  Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2.

Authors:  Xia Xiao; Conghui Wang; Ying Wang; Xiaojing Dong; Tao Jiao; Zhendong Zhao; Lili Ren; Charles S Dela Cruz; Lokesh Sharma; Xiaobo Lei; Jianwei Wang
Journal:  Front Immunol       Date:  2020-11-25       Impact factor: 7.561

Review 6.  Estrogen Receptor Modulators in Viral Infections Such as SARS-CoV-2: Therapeutic Consequences.

Authors:  Nikita Abramenko; Fréderic Vellieux; Petra Tesařová; Zdeněk Kejík; Robert Kaplánek; Lukáš Lacina; Barbora Dvořánková; Daniel Rösel; Jan Brábek; Adam Tesař; Milan Jakubek; Karel Smetana
Journal:  Int J Mol Sci       Date:  2021-06-18       Impact factor: 5.923

Review 7.  Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19.

Authors:  Jan Brábek; Milan Jakubek; Fréderic Vellieux; Jiří Novotný; Michal Kolář; Lukáš Lacina; Pavol Szabo; Karolína Strnadová; Daniel Rösel; Barbora Dvořánková; Karel Smetana
Journal:  Int J Mol Sci       Date:  2020-10-26       Impact factor: 5.923

8.  Vascular Abnormalities Detected with Chest CT in COVID-19: Spectrum, Association with Parenchymal Lesions, Cardiac Changes, and Correlation with Clinical Severity (COVID-CAVA Study).

Authors:  Salah D Qanadli; Alexander W Sauter; Hatem Alkadhi; Andreas Christe; Pierre-Alexandre Poletti; Lukas Ebner; David C Rotzinger
Journal:  Diagnostics (Basel)       Date:  2021-03-29

9.  Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.

Authors:  Katarzyna Szurkowska; Paulina Kazimierczak; Joanna Kolmas
Journal:  Int J Mol Sci       Date:  2021-03-13       Impact factor: 5.923

10.  Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants.

Authors:  Isabella A Guedes; Leon S C Costa; Karina B Dos Santos; Ana L M Karl; Gregório K Rocha; Iury M Teixeira; Marcelo M Galheigo; Vivian Medeiros; Eduardo Krempser; Fábio L Custódio; Helio J C Barbosa; Marisa F Nicolás; Laurent E Dardenne
Journal:  Sci Rep       Date:  2021-03-10       Impact factor: 4.379
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