Mi-Kyoung Lim1, Jihyung Yoo1, Dong-Hyuk Sheen1, Chunhwa Ihm2,3, Sang Kwang Lee3, Soon Ae Kim4. 1. Department of Internal Medicine, School of Medicine, Eulji University, Daejeon, Republic of Korea. 2. Department of Laboratory Medicine, School of Medicine, Eulji University, Daejeon, Republic of Korea. 3. Eulji Medical Bio Research Center, Eulji University, Daejeon, Republic of Korea. 4. Department of Pharmacology, School of Medicine, Eulji University, Daejeon, Republic of Korea sakim@eulji.ac.kr.
Abstract
BACKGROUND/AIM: It has been found that microRNAs (miRNA) affect rheumatoid arthritis (RA) pathophysiology. This study aimed to identify novel serum exosomal miRNAs related to RA disease activity in patients with an inadequate treatment response. PATIENTS AND METHODS: The sample population comprised clinical remission (CR) and non-clinical remission (non-CR) groups of RA patients. To identify potent miRNA markers for RA disease activity, miRNA array and qPCR were performed after patient serum exosomes preparation. RESULTS: Has-miR-1915-3p and has-miR-6511b-5p were significantly higher in the serum exosomes of the CR group. The level of serum C-reactive protein (CRP) was negatively correlated with has-miR-1915-3p level in serum exosomes. CONCLUSION: Has-miR-1915-3p may be a potential marker for Korean RA disease activity. Copyright
BACKGROUND/AIM: It has been found that microRNAs (miRNA) affect rheumatoid arthritis (RA) pathophysiology. This study aimed to identify novel serum exosomal miRNAs related to RA disease activity in patients with an inadequate treatment response. PATIENTS AND METHODS: The sample population comprised clinical remission (CR) and non-clinical remission (non-CR) groups of RA patients. To identify potent miRNA markers for RA disease activity, miRNA array and qPCR were performed after patient serum exosomes preparation. RESULTS: Has-miR-1915-3p and has-miR-6511b-5p were significantly higher in the serum exosomes of the CR group. The level of serum C-reactive protein (CRP) was negatively correlated with has-miR-1915-3p level in serum exosomes. CONCLUSION: Has-miR-1915-3p may be a potential marker for Korean RA disease activity. Copyright
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