Nicolae Bacalbasa1,2,3, Camelia Diaconu4,5, Laura Iliescu4,6, Cornel Savu7,8, Carmen Savu9, Cristian Balalau10,11, Mihai Dimitriu1,12, Alexandru Filipescu1,13, Ovidiu Gabriel Bratu14,15, Adrian Neacsu16, Dragos Cretoiu1,17, Ioana Halmaciu18, Irina Balescu19. 1. Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. 2. Department of Obstetrics and Gynecology, I. Cantacuzino Clinical Hospital, Bucharest, Romania. 3. Department of Visceral Surgery, Center of Excellence in Translational Medicine Fundeni Clinical Institute, Bucharest, Romania. 4. Department of Internal Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. 5. Department of Internal Medicine, University Emergency Hospital Bucharest, Bucharest, Romania. 6. Department of Internal Medicine, Fundeni Clinical Institute, Bucharest, Romania. 7. Department of Thoracic Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. 8. Department of Thoracic Surgery, Marius Nasta Institute of Pneumonology Bucharest, Romania. 9. Department of Anesthesiology, Fundeni Clinical Institute, Bucharest, Romania. 10. Department of Surgery, Pantelimon Clinical Hospital, Bucharest, Romania. 11. Department of Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. 12. Department of Obstetrics and Gynecology, St. Pantelimon Emergency Clinical Hospital, Bucharest, Romania. 13. Department of Obstetrics and Gynecology, Elias Emergency Hospital, Bucharest, Romania. 14. Department of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. 15. Department of Urology, Emergency Central Military Hospital, Academy of Romanian Scientists, Bucharest, Romania. 16. Department of Obstetrics and Gynecology, St. John Emergency Clinical Hospital, Bucharest, Romania. 17. Alessandrescu-Rusescu National Institute of Mother and Child Health, Fetal Medicine Excellence Research Center, Bucharest, Romania. 18. Department of Anatomy, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu Mureș, Romania. 19. Department of Surgery, Ponderas Academic Hospital, Bucharest, Romania irina.balescu@ponderas-ah.ro.
Abstract
BACKGROUND/AIM: Endometrial cancer is one of the most commonly encountered malignancies among obese women worldwide, a strong causality relationship being established between the two entities. Furthermore, obesity is also associated with metabolic syndrome; the aim of this study was to investigate the effect of metabolic syndrome on the postoperative outcomes of patients with endometrial cancer. PATIENTS AND METHODS: Data of 23 patients diagnosed with endometrial cancer and metabolic syndrome were retrospectively reviewed and compared to the those of a control group of patients diagnosed with endometrial cancer in the absence of metabolic syndrome. RESULTS: Patients in the first group presented significantly higher values of body mass index when compared to the control group. There were no significant differences in terms of stage, histopathological subtype or degree of differentiation between the two groups. The completeness of cytoreduction was lower among patients with metabolic syndrome, however, this did not reach statistical significance (p=0.08). Although the rate of complete debulking was lower among those with metabolic syndrome, the rates of postoperative complications were significantly higher. CONCLUSION: The association of metabolic syndrome significantly influences the risk of postoperative complications in patients with endometrial cancer; moreover, in certain cases, it might preclude the achievement of freedom from residual disease. Copyright
BACKGROUND/AIM: Endometrial cancer is one of the most commonly encountered malignancies among obesewomen worldwide, a strong causality relationship being established between the two entities. Furthermore, obesity is also associated with metabolic syndrome; the aim of this study was to investigate the effect of metabolic syndrome on the postoperative outcomes of patients with endometrial cancer. PATIENTS AND METHODS: Data of 23 patients diagnosed with endometrial cancer and metabolic syndrome were retrospectively reviewed and compared to the those of a control group of patients diagnosed with endometrial cancer in the absence of metabolic syndrome. RESULTS:Patients in the first group presented significantly higher values of body mass index when compared to the control group. There were no significant differences in terms of stage, histopathological subtype or degree of differentiation between the two groups. The completeness of cytoreduction was lower among patients with metabolic syndrome, however, this did not reach statistical significance (p=0.08). Although the rate of complete debulking was lower among those with metabolic syndrome, the rates of postoperative complications were significantly higher. CONCLUSION: The association of metabolic syndrome significantly influences the risk of postoperative complications in patients with endometrial cancer; moreover, in certain cases, it might preclude the achievement of freedom from residual disease. Copyright
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