Hung-Yi Chen1,2, Shu-Fen Peng3,4, Fu-Shin Chueh5, Jin-Cherng Lien6, Yu-Cheng Chou7,8, Wen-Wen Huang9, Yi-Ping Huang10, Jye-Yu Huang9, Jung-Yu Kuo9, Wan-Ni Huang9, Shou-Yi Sheng9, Hao-Yun Tung9. 1. Department of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C. t20811@mail.cmuh.org.tw hungyi@mail.cmu.edu.tw. 2. Department of Pharmacy, China Medical University Beigang Hospital, Yunlin, Taiwan, R.O.C. 3. Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C. t20811@mail.cmuh.org.tw hungyi@mail.cmu.edu.tw. 4. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C. 5. Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C. 6. Department of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C. 7. Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C. 8. Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C. 9. Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C. 10. Department of Physiology, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Abstract
BACKGROUND/AIM: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. Therefore we investigated the antitumor effects of DMC on a HeLa cell xenograft model in nude mice in this study. MATERIALS AND METHODS: Twenty-four nude mice were subcutaneously injected with HeLa cells. All mice were randomly divided into control, low-dose DMC (30 mg/kg), and high-dose DMC (50 mg/kg) groups and individual mice were treated intraperitoneally accordingly every 2 days. RESULTS: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. CONCLUSION: These effects and findings might provide evidence for investigating the potential use of DMC as an anti-cervical cancer drug in the future. Copyright
BACKGROUND/AIM: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various humancancer cells in vitro and in vivo. Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. Therefore we investigated the antitumor effects of DMC on a HeLa cell xenograft model in nude mice in this study. MATERIALS AND METHODS: Twenty-four nude mice were subcutaneously injected with HeLa cells. All mice were randomly divided into control, low-dose DMC (30 mg/kg), and high-dose DMC (50 mg/kg) groups and individual mice were treated intraperitoneally accordingly every 2 days. RESULTS:DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. CONCLUSION: These effects and findings might provide evidence for investigating the potential use of DMC as an anti-cervical cancer drug in the future. Copyright
Authors: Elham Beyranvand Nejad; Marij J P Welters; Ramon Arens; Sjoerd H van der Burg Journal: Expert Opin Biol Ther Date: 2016-11-16 Impact factor: 4.388
Authors: Lindsey A Torre; Freddie Bray; Rebecca L Siegel; Jacques Ferlay; Joannie Lortet-Tieulent; Ahmedin Jemal Journal: CA Cancer J Clin Date: 2015-02-04 Impact factor: 508.702