Peungchaleoy Thammanichanon1, Aunwaya Kaewpitak2, Thunwa Binlateh3, Chidchanok Leethanakul4. 1. Orthodontic Section, Department of Preventive Dentistry, Faculty of Dentistry, Prince of Songkla University, Hat Yai, Thailand. 2. Department of Preventive Dentistry, Faculty of Dentistry, Prince of Songkla University, Hat Yai, Thailand. 3. Department of Physiology, Faculty of Science, Prince of Songkla University, Hat Yai, Thailand. 4. Orthodontic Section, Department of Preventive Dentistry, Faculty of Dentistry, Prince of Songkla University, Hat Yai, Thailand chidchanok.l@psu.ac.th nokleethanakul@yahoo.com.
Abstract
BACKGROUND/AIM: The transient receptor potential vanilloid 1 (TRPV1) ion receptor is involved in the release of calcitonin gene-related peptide (CGRP), a major contributor to orthodontic pain. Approaches that attenuate expression of TRPV1 and CGRP may reduce orthodontic pain. We explored the ability of high-frequency interval vibration to reduce orthodontic pain. MATERIALS AND METHODS: Orthodontic force (50 g) was applied to both maxillary first molars in 8-week-old Wistar rats (n=72). Vibration was applied at 125 Hz for 15 min/day. Duration of face grooming was assessed as a measure of orthodontic pain. Immunofluorescence and western blotting were used to assess TRPV1 and CGRP in the trigeminal ganglia. RESULTS: Compared to orthodontic force alone, application of vibration significantly decreased the duration of face grooming at 24 h and day 3 and reduced expression of TRPV1 and CGRP at 24 h. CONCLUSION: Vibration represents a promising mechanical approach to reduce orthodontic pain. Copyright
BACKGROUND/AIM: The transient receptor potential vanilloid 1 (TRPV1) ion receptor is involved in the release of calcitonin gene-related peptide (CGRP), a major contributor to orthodontic pain. Approaches that attenuate expression of TRPV1 and CGRP may reduce orthodontic pain. We explored the ability of high-frequency interval vibration to reduce orthodontic pain. MATERIALS AND METHODS: Orthodontic force (50 g) was applied to both maxillary first molars in 8-week-old Wistar rats (n=72). Vibration was applied at 125 Hz for 15 min/day. Duration of face grooming was assessed as a measure of orthodontic pain. Immunofluorescence and western blotting were used to assess TRPV1 and CGRP in the trigeminal ganglia. RESULTS: Compared to orthodontic force alone, application of vibration significantly decreased the duration of face grooming at 24 h and day 3 and reduced expression of TRPV1 and CGRP at 24 h. CONCLUSION: Vibration represents a promising mechanical approach to reduce orthodontic pain. Copyright
Authors: Rui Guo; Yang Zhou; Hu Long; Di Shan; Jing Wen; Huimin Hu; Hong Yang; Zhouqiang Wu; Wenli Lai Journal: Int J Oral Sci Date: 2019-03-11 Impact factor: 6.344
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