Bérengère Beauplet1,2,3, Ophélie Soulie4, Jean-Yves Niemier5,6, Cécile Pons-Peyneau7, Drifa Belhadi8,9, Camille Couffignal8,9, Virginie Fossey-Diaz10,11. 1. Normandy Interregional Oncogeriatric Coordination Unit, Rue Bailey, 14000, Caen, France. beauplet-b@chu-caen.fr. 2. Department of Geriatric Medicine, Caen Universitary Hospital Center, Avenue Côte de Nacre, 14 033 cedex 9, Caen, France. beauplet-b@chu-caen.fr. 3. Normandie University, UniCaen, INSERM, U1086, ANTICIPE, Avenue du General Harris, 14000, Caen, France. beauplet-b@chu-caen.fr. 4. Psycho-Oncology Unit, Supportive Care Department, Curie Institute, 75005, Paris, France. 5. Department of Geriatric Oncology, Nancy University Hospital Center, 54511, Vandoeuvre-lès-Nancy, France. 6. Lorraine Oncogeriatric Coordination Unit, 54511, Vandoeuvre-lès-Nancy, France. 7. Department of Psychiatry, Chardon-Lagache Hospital, 75016, Paris, France. 8. Biostatistics and Clinical Research Unit, AP-HP Northern Group, Bichat-Claude Bernard Hospital, Paris, France. 9. Paris University, INSERM, CIC-EC 1425, Bichat-Claude Bernard Hospital, Paris, France. 10. Department of Geriatric Medicine and Palliative Care, Bretonneau Hospital Center, 75018, Paris, France. 11. Oncogeriatric Coordination Unit, Paris North, 75018, Paris, France.
Abstract
INTRODUCTION: Depression symptoms, frequently diagnosed in older patients with cancer, impacts on oncological treatment feasibility. The Francophone Society of Geriatric Oncology (SOFOG) has initiated a systematic review on depression treatment in older patients with cancer, to advocate guidelines. DATA SOURCES: Medline via PubMed, Embase, CENTRAL. METHODS: We included randomized and non-randomized controlled trials, reviews and meta-analysis, retrospective and prospective cohort studies, qualitative studies, and guidelines published between January 2013 and December 2018 that involved depression with cancer in which the entire sample or a sub-group aged 65 and above. Efficacy and tolerance of depression treatment were examined, as a primary or secondary outcome, among articles published in French or English. RESULTS: Of 3171 references, only seven studies met our eligibility criteria. This systematic review reveals a lack of evidence-based knowledge in this field, preventing from making any recommendations on drug and non-drug therapies. It has highlighted the need for multidisciplinary collaboration with the French and Francophone Society of Psycho-Oncology. CONCLUSION: In clinical practice, we advise health professionals to use the screening process not as a result but rather as an opportunity to engage with the patient and also to question the need for antidepressants and non-drug therapies.
INTRODUCTION:Depression symptoms, frequently diagnosed in older patients with cancer, impacts on oncological treatment feasibility. The Francophone Society of Geriatric Oncology (SOFOG) has initiated a systematic review on depression treatment in older patients with cancer, to advocate guidelines. DATA SOURCES: Medline via PubMed, Embase, CENTRAL. METHODS: We included randomized and non-randomized controlled trials, reviews and meta-analysis, retrospective and prospective cohort studies, qualitative studies, and guidelines published between January 2013 and December 2018 that involved depression with cancer in which the entire sample or a sub-group aged 65 and above. Efficacy and tolerance of depression treatment were examined, as a primary or secondary outcome, among articles published in French or English. RESULTS: Of 3171 references, only seven studies met our eligibility criteria. This systematic review reveals a lack of evidence-based knowledge in this field, preventing from making any recommendations on drug and non-drug therapies. It has highlighted the need for multidisciplinary collaboration with the French and Francophone Society of Psycho-Oncology. CONCLUSION: In clinical practice, we advise health professionals to use the screening process not as a result but rather as an opportunity to engage with the patient and also to question the need for antidepressants and non-drug therapies.
Entities:
Keywords:
80 and older; Aged; Depression; Depressive disorder; Geriatrics; Neoplasms
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