Hanna Kallankari1,2, Virva Saunavaara3,4, Riitta Parkkola5, Leena Haataja6, Mikko Hallman7, Tuula Kaukola7,8. 1. PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland. hanna.kallankari@oulu.fi. 2. Department of Child Neurology, Oulu University Hospital, P.O. Box 23, FIN-90029 OYS, Oulu, Finland. hanna.kallankari@oulu.fi. 3. PET Center, Turku University Hospital, Turku, Finland. 4. Department of Medical Physics, Turku University Hospital, Turku, Finland. 5. Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland. 6. Department of Child Neurology, Children and Adolescents, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. 7. PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland. 8. Department of Neonatology, Oulu University Hospital, Oulu, Finland.
Abstract
BACKGROUND: Very preterm birth can disturb brain maturation and subject these high-risk children to neurocognitive difficulties later. OBJECTIVE: The aim of the study was to evaluate the impact of prematurity on microstructure of frontostriatal tracts in children with no severe neurologic impairment, and to study whether the diffusion tensor imaging metrics of frontostriatal tracts correlate to executive functioning. MATERIALS AND METHODS: The prospective cohort study comprised 54 very preterm children (mean gestational age 28.8 weeks) and 20 age- and gender-matched term children. None of the children had severe neurologic impairment. The children underwent diffusion tensor imaging and neuropsychological assessments at a mean age of 9 years. We measured quantitative diffusion tensor imaging metrics of frontostriatal tracts using probabilistic tractography. We also administered five subtests from the Developmental Neuropsychological Assessment, Second Edition, to evaluate executive functioning. RESULTS: Very preterm children had significantly higher fractional anisotropy and axial diffusivity values (P<0.05, corrected for multiple comparison) in dorsolateral prefrontal caudate and ventrolateral prefrontal caudate tracts as compared to term-born children. We found negative correlations between the diffusion tensor imaging metrics of frontostriatal tracts and inhibition functions (P<0.05, corrected for multiple comparison) in very preterm children. CONCLUSION: Prematurity has a long-term effect on frontostriatal white matter microstructure that might contribute to difficulties in executive functioning.
BACKGROUND: Very preterm birth can disturb brain maturation and subject these high-risk children to neurocognitive difficulties later. OBJECTIVE: The aim of the study was to evaluate the impact of prematurity on microstructure of frontostriatal tracts in children with no severe neurologic impairment, and to study whether the diffusion tensor imaging metrics of frontostriatal tracts correlate to executive functioning. MATERIALS AND METHODS: The prospective cohort study comprised 54 very preterm children (mean gestational age 28.8 weeks) and 20 age- and gender-matched term children. None of the children had severe neurologic impairment. The children underwent diffusion tensor imaging and neuropsychological assessments at a mean age of 9 years. We measured quantitative diffusion tensor imaging metrics of frontostriatal tracts using probabilistic tractography. We also administered five subtests from the Developmental Neuropsychological Assessment, Second Edition, to evaluate executive functioning. RESULTS: Very preterm children had significantly higher fractional anisotropy and axial diffusivity values (P<0.05, corrected for multiple comparison) in dorsolateral prefrontal caudate and ventrolateral prefrontal caudate tracts as compared to term-born children. We found negative correlations between the diffusion tensor imaging metrics of frontostriatal tracts and inhibition functions (P<0.05, corrected for multiple comparison) in very preterm children. CONCLUSION: Prematurity has a long-term effect on frontostriatal white matter microstructure that might contribute to difficulties in executive functioning.
Entities:
Keywords:
Children; Diffusion tensor imaging; Frontostriatal tracts; Magnetic resonance imaging; Premature birth; Tractography; White matter
Authors: Lars M Rimol; Violeta L Botellero; Knut J Bjuland; Gro C C Løhaugen; Stian Lydersen; Kari Anne I Evensen; Ann-Mari Brubakk; Live Eikenes; Marit S Indredavik; Marit Martinussen; Anastasia Yendiki; Asta K Håberg; Jon Skranes Journal: Neuroimage Date: 2018-11-28 Impact factor: 6.556
Authors: Alina Jurcoane; Marcel Daamen; Lukas Scheef; Josef G Bäuml; Chun Meng; Afra M Wohlschläger; Christian Sorg; Barbara Busch; Nicole Baumann; Dieter Wolke; Peter Bartmann; Elke Hattingen; Henning Boecker Journal: Hum Brain Mapp Date: 2015-10-21 Impact factor: 5.038