Connections in the cambium, receptors in the ring.

In plants, pluripotent cells in meristems divide to provide cells for the formation of postembryonic tissues. The cambium is the meristem from which the vascular tissue is derived and is the main driver for secondary (radial) growth in dicots. Xylem and phloem are specified on opposing sides of the cambium, and tightly regulated cell divisions ensure their spatial separation. Peptide ligands, phytohormones, and their receptors are central to maintaining this patterning and regulating proliferation. Here, we describe recent advances in our understanding of how these signals are integrated to control vascular development and secondary growth.