Huiwen Song1, Xianbin Wang1, Yubao Lian1, Tuer Wan2. 1. Department of Infectious Diseases, Saming First Hospital Affiliated with Fujian Medical University, Fujian Province, China. 2. Department of Imaging Medicine, Saming First Hospital Affiliated with Fujian Medical University, Fujian Province, China.
Abstract
OBJECTIVE: Clinical characteristics of patients with pyogenic liver abscess (PLA) of varying etiologies may be different. This study aimed to analyze the clinical characteristics, pathogenic bacteria, treatment, and prognosis of patients with PLA associated with diabetes and biliary disease. METHODS: Clinical, imaging, and laboratory data from 202 inpatients with PLA were retrospectively analyzed. RESULTS: Eighty-eight patients (43.6%) had a history of diabetes, 73 (36.1%) had a history of underlying biliary tract disease, and 24 (11.9%) had both the diseases. The level of C-reactive protein (CRP) increased in 99.2% (119/120) patients, and the level of procalcitonin (PCT) increased in 95.5% (148/155) patients. The main pathogen of PLA was Klebsiella pneumoniae. The incidence of bloodstream infection increased by 34.4% (22/64) in patients with PLA that was associated with diabetes mellitus, and that of K. pneumoniae infection was 88.6% (39/44). The readmission rate for patients with PLA with underlying biliary diseases was 10.2 to 12.5%. CONCLUSION: The main pathogen of PLA is K. pneumoniae, which is sensitive to most antibiotics. Patients with PLA associated with diabetes were more likely to have bloodstream infections, and the recurrence rate of PLA with underlying biliary diseases was higher than without biliary duct disease.
OBJECTIVE: Clinical characteristics of patients with pyogenic liver abscess (PLA) of varying etiologies may be different. This study aimed to analyze the clinical characteristics, pathogenic bacteria, treatment, and prognosis of patients with PLA associated with diabetes and biliary disease. METHODS: Clinical, imaging, and laboratory data from 202 inpatients with PLA were retrospectively analyzed. RESULTS: Eighty-eight patients (43.6%) had a history of diabetes, 73 (36.1%) had a history of underlying biliary tract disease, and 24 (11.9%) had both the diseases. The level of C-reactive protein (CRP) increased in 99.2% (119/120) patients, and the level of procalcitonin (PCT) increased in 95.5% (148/155) patients. The main pathogen of PLA was Klebsiella pneumoniae. The incidence of bloodstream infection increased by 34.4% (22/64) in patients with PLA that was associated with diabetes mellitus, and that of K. pneumoniaeinfection was 88.6% (39/44). The readmission rate for patients with PLA with underlying biliary diseases was 10.2 to 12.5%. CONCLUSION: The main pathogen of PLA is K. pneumoniae, which is sensitive to most antibiotics. Patients with PLA associated with diabetes were more likely to have bloodstream infections, and the recurrence rate of PLA with underlying biliary diseases was higher than without biliary duct disease.
Authors: Liisa Meddings; Robert P Myers; James Hubbard; Abdel Aziz Shaheen; Kevin B Laupland; Elijah Dixon; Carla Coffin; Gilaad G Kaplan Journal: Am J Gastroenterol Date: 2009-11-03 Impact factor: 10.864
Authors: Helen M Heneghan; Nuala A Healy; Sean T Martin; Ronan S Ryan; Niamh Nolan; Oscar Traynor; Ronan Waldron Journal: BMC Res Notes Date: 2011-03-24
Authors: Chang Hun Lee; Hoon Gil Jo; Eun Young Cho; Jae Sun Song; Gum Mo Jung; Yong Keun Cho; Seung Young Seo; Seong Hun Kim; Sang Wook Kim; Seung Ok Lee; Soo Teik Lee; In Hee Kim Journal: BMC Infect Dis Date: 2021-02-11 Impact factor: 3.090