Literature DB >> 3286455

Multihormonal regulation of thyroglobulin production by the OVNIS 6H thyroid cell line.

A Aouani1, S Hovsépian, G Fayet.   

Abstract

The hormonal regulation of thyroglobulin production has been studied using a clone of the ovine thyroid cell line: OVNIS 6H. 3 among the 6 hormones proposed for serum replacement are required for an optimal thyroglobulin production; insulin, hydrocortisone and thyrotropin. Insulin alone stimulates thyroglobulin production. The presence of insulin is also required to observe hydrocortisone and TSH stimulations. Newborn calf serum inhibits thyroglobulin production. The best conditions for optimal thyroglobulin expression and TSH responsiveness are obtained in serum-free medium supplemented with 5 micrograms/ml insulin, 100 nM hydrocortisone and 1 mU/ml TSH.

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Year:  1988        PMID： 3286455     DOI： 10.1055/s-2007-1010760

Source DB:  PubMed          Journal:  Horm Metab Res        ISSN： 0018-5043            Impact factor:   2.936


  2 in total

1.  Insulin and insulin-like growth factor I exert different effects on plasminogen activator production or cell growth in the ovine thyroid cell line OVNIS.

Authors:  B Degryse; F Maisonobe; S Hovsépian; G Fayet
Journal:  J Endocrinol Invest       Date:  1991-11       Impact factor: 4.256

2.  Differentiation expression during proliferative activity induced through different pathways: in situ hybridization study of thyroglobulin gene expression in thyroid epithelial cells.

Authors:  V Pohl; P P Roger; D Christophe; G Pattyn; G Vassart; J E Dumont
Journal:  J Cell Biol       Date:  1990-08       Impact factor: 10.539
  2 in total

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