Yihai Liu1, Mingyue Wu1, Jiamin Xu1, Dujuan Sha2, Biao Xu3, Lina Kang4. 1. Department of Cardiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China. 2. Department of General Medicine, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China. Electronic address: tbwen0912@126.com. 3. Department of Cardiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China. Electronic address: xubiao62@nju.edu.cn. 4. Department of Cardiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China. Electronic address: kanglina@njglyy.com.
Abstract
BACKGROUND AND AIMS: Triglyceride and glycose (TyG) index has been viewed as a reliable surrogate of cardiovascular disease (CVD) risk. We hypothesized that elevated TyG index is associated with increased risk of subclinical myocardial injury (SC-MI). METHODS AND RESULTS: A total of 6093 participants without history of CVD were extracted from the third National Health and Nutrition Examination Survey (NHANES III). SC-MI was defined by cardiac infarction/injury score (CIIS) ≥10. Multivariate logistic regression was performed to examine the association between TyG index (as a qualitative or quantitative variable) and SC-MI. TyG index was positively correlated with CIIS (β = 0.54; p = 0.004) in the multivariable linear regression analysis. In a multivariable model, TyG index was independently associated with an increased risk of SC-MI (OR = 1.17, 95% CI: 1.05 to 1.30; p = 0.004). Also, TyG>9.00 increased the risk of SC-MI (OR = 1.21, 95% CI: 1.03 to 1.43; p = 0.024) independent of other risk factors. CONCLUSION: Elevated TyG index increases the risk of CIIS and SC-MI, which could be a new biomarker in the clinical practice.
BACKGROUND AND AIMS: Triglyceride and glycose (TyG) index has been viewed as a reliable surrogate of cardiovascular disease (CVD) risk. We hypothesized that elevated TyG index is associated with increased risk of subclinical myocardial injury (SC-MI). METHODS AND RESULTS: A total of 6093 participants without history of CVD were extracted from the third National Health and Nutrition Examination Survey (NHANES III). SC-MI was defined by cardiac infarction/injury score (CIIS) ≥10. Multivariate logistic regression was performed to examine the association between TyG index (as a qualitative or quantitative variable) and SC-MI. TyG index was positively correlated with CIIS (β = 0.54; p = 0.004) in the multivariable linear regression analysis. In a multivariable model, TyG index was independently associated with an increased risk of SC-MI (OR = 1.17, 95% CI: 1.05 to 1.30; p = 0.004). Also, TyG>9.00 increased the risk of SC-MI (OR = 1.21, 95% CI: 1.03 to 1.43; p = 0.024) independent of other risk factors. CONCLUSION: Elevated TyG index increases the risk of CIIS and SC-MI, which could be a new biomarker in the clinical practice.