Literature DB >> 32863

Determination of monoureides in biological fluids by high-pressure-liquid-chromatography.

M Eichelbaum, B Sonntag, G von Unruh.   

Abstract

A sensitive and specific method for the simultaneous determination of bromisoval, carbromal, and methaqualone is described. The drugs are adsorbed from serum onto charcoal at pH 11 and eluted from it with organic solvent. The eluate is separated by high-pressure liquid-chromatography on reverse phase (RP 18) column using acetonitrile: water (26 : 74 by volume) as mobile phase. The eluted drugs are detected by uv-absorption at 210 nm. The method is sensitive, specific, precise, and accurate.

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Year:  1978        PMID： 32863     DOI： 10.1007/bf00354090

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  11 in total

1.  [On the toxicology of carbromal. I. Estimation of carbromal and its hypnotically active metabolites in rats and humans (author's transl)].

Authors:  H W Vohland; S Hadisoemarto; B Wanke
Journal:  Arch Toxicol       Date:  1976-09-15       Impact factor: 5.153

2.  Proceedings: Highly reliable identification of drugs and their metabolites in body fluids using computerized gas chromatography-mass spectrometry.

Authors:  W Ehrenthal; K Pfleger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

3.  [On the toxicology of carbromal. II. Pharmacokinetics of carbromal and its hypnotically active metabolites in the rat (author's transl)].

Authors:  H W Vohland; S Hadisoemarto; B Wanke
Journal:  Arch Toxicol       Date:  1977-08-09       Impact factor: 5.153

4.  Separation and quantitative determination of acecarbromal, carbromal, and bromisoval as well as their main metabolites by means of high-pressure liquid chromatographic analysis.

Authors:  M Höbel; G Bender
Journal:  Arch Toxicol       Date:  1977-08-09       Impact factor: 5.153

5.  Simultaneous high-pressure liquid-chromatographic determination of some anticonvulsants in serum.

Authors:  R F Adams; F L Vandemark
Journal:  Clin Chem       Date:  1976-01       Impact factor: 8.327

6.  [Carbromal intoxication: influence of hemodialysis and hemoperfusion].

Authors:  H W Leber; R H Geissler; M Faber; D Post
Journal:  Klin Wochenschr       Date:  1976-06-01

7.  [Clinical features and treatment of carbromal poisoning].

Authors:  B Grabensee; K Hofmann; W Jax; T Königshausen; E Schnurr; E Schröder
Journal:  Dtsch Med Wochenschr       Date:  1972-12-08       Impact factor: 0.628

8.  Use of charcoal to concentrate drugs from urine before drug analysis.

Authors:  J M Meola; M Vanko
Journal:  Clin Chem       Date:  1974-02       Impact factor: 8.327

9.  [Treatment possibilities in bromcarbamide poisoning].

Authors:  B Grabensee; K Hofmann; W Jax; T Königshausen; E Schnurr; E Schröder
Journal:  Med Welt       Date:  1973-04-27

10.  [The clinical course of severe carbromal poisoning (author's transl)].

Authors:  G Grosse; W Höfer; H Gruska; K H Beyer; S Kubicki; T Schirop
Journal:  Klin Wochenschr       Date:  1974-01-01
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  2 in total

1.  Determination of monoureides in biological fluids by high-pressure-liquid-chromatography.

Authors:  D R Uges; P Bouma
Journal:  Arch Toxicol       Date:  1979-04-23       Impact factor: 5.153

2.  Stereoselectivity in the urinary excretion of the mercapturates of (R-) and (S-) alpha-bromoisovalerylurea in man.

Authors:  J M te Koppele; C Schipper; D D Breimer; G J Mulder
Journal:  Br J Clin Pharmacol       Date:  1989-08       Impact factor: 4.335
  2 in total

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