Masoumeh Rostampour1, Khadijeh Noori2, Maryam Heidari3, Reza Fadaei4, Masoud Tahmasian5, Habibolah Khazaie6, Mojtaba Zarei7. 1. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: rostampour.ma@gmail.com. 2. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: kh.noori89@gmail.com. 3. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: maryam74heidari@gmail.com. 4. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: reza.fadaei19@gmail.com. 5. Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran. Electronic address: m_tahmasian@sbu.ac.ir. 6. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: hakhazaie@gmail.com. 7. Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran. Electronic address: mzarei@me.com.
Abstract
BACKGROUND: Obstructive sleep apnea (OSA) is a common sleep disorder, which causes wide range of neurological and psychiatric symptoms. Several studies demonstrated structural and functional brain alterations using magnetic resonance imaging (MRI) techniques. Recently, diffusion-based brain MRI studies in patients with OSA showed changes in diffusion measures that represent various impairments of white matter (WM) integrity. The various finding may be due to diffusion indices employed for detection of neural impairment at the microstructural level, phase of the disease and the goals of studies. OBJECTIVES: We aimed to identify a common abnormal WM pattern across the previous studies. METHODS: We reviewed related literature in EMBASE, Scopus and PubMed databases and identified 13 studies that meet our selection criteria. RESULTS: The current data pointed to WM integrity changes in corpus callosum, cingulate cortex, corticospinal tract, insular cortex, basal ganglia, and limbic sites. These regions mainly contribute in mood, autonomic and cardiovascular regulation. CONCLUSION: Widespread use of diffusion magnetic resonance imaging (dMRI) parameters provides insight into the pathophysiology of OSA, stage of the disease and planning appropriate treatments in future.
BACKGROUND:Obstructive sleep apnea (OSA) is a common sleep disorder, which causes wide range of neurological and psychiatric symptoms. Several studies demonstrated structural and functional brain alterations using magnetic resonance imaging (MRI) techniques. Recently, diffusion-based brain MRI studies in patients with OSA showed changes in diffusion measures that represent various impairments of white matter (WM) integrity. The various finding may be due to diffusion indices employed for detection of neural impairment at the microstructural level, phase of the disease and the goals of studies. OBJECTIVES: We aimed to identify a common abnormal WM pattern across the previous studies. METHODS: We reviewed related literature in EMBASE, Scopus and PubMed databases and identified 13 studies that meet our selection criteria. RESULTS: The current data pointed to WM integrity changes in corpus callosum, cingulate cortex, corticospinal tract, insular cortex, basal ganglia, and limbic sites. These regions mainly contribute in mood, autonomic and cardiovascular regulation. CONCLUSION: Widespread use of diffusion magnetic resonance imaging (dMRI) parameters provides insight into the pathophysiology of OSA, stage of the disease and planning appropriate treatments in future.
Authors: Masoud Tahmasian; André Aleman; Ole A Andreassen; Zahra Arab; Marion Baillet; Francesco Benedetti; Tom Bresser; Joanna Bright; Michael W L Chee; Daphne Chylinski; Wei Cheng; Michele Deantoni; Martin Dresler; Simon B Eickhoff; Claudia R Eickhoff; Torbjørn Elvsåshagen; Jianfeng Feng; Jessica C Foster-Dingley; Habib Ganjgahi; Hans J Grabe; Nynke A Groenewold; Tiffany C Ho; Seung Bong Hong; Josselin Houenou; Benson Irungu; Neda Jahanshad; Habibolah Khazaie; Hosung Kim; Ekaterina Koshmanova; Desi Kocevska; Peter Kochunov; Oti Lakbila-Kamal; Jeanne Leerssen; Meng Li; Annemarie I Luik; Vincenzo Muto; Justinas Narbutas; Gustav Nilsonne; Victoria S O'Callaghan; Alexander Olsen; Ricardo S Osorio; Sara Poletti; Govinda Poudel; Joyce E Reesen; Liesbeth Reneman; Mathilde Reyt; Dieter Riemann; Ivana Rosenzweig; Masoumeh Rostampour; Amin Saberi; Julian Schiel; Christina Schmidt; Anouk Schrantee; Emma Sciberras; Tim J Silk; Kang Sim; Hanne Smevik; Jair C Soares; Kai Spiegelhalder; Dan J Stein; Puneet Talwar; Sandra Tamm; Giana L Teresi; Sofie L Valk; Eus Van Someren; Gilles Vandewalle; Maxime Van Egroo; Henry Völzke; Martin Walter; Rick Wassing; Frederik D Weber; Antoine Weihs; Lars Tjelta Westlye; Margaret J Wright; Mon-Ju Wu; Nathalia Zak; Mojtaba Zarei Journal: J Sleep Res Date: 2021-04-28 Impact factor: 3.981
Authors: Victoria Fleming; Brianna Piro-Gambetti; Austin Bazydlo; Matthew Zammit; Andrew L Alexander; Bradley T Christian; Benjamin Handen; David T Plante; Sigan L Hartley Journal: Brain Sci Date: 2021-10-05
Authors: Diego Z Carvalho; Erik K St Louis; Scott A Przybelski; Timothy I Morgenthaler; Mary M Machulda; Bradley F Boeve; Ronald C Petersen; Clifford R Jack; Jonathan Graff-Radford; Prashanthi Vemuri; Michelle M Mielke Journal: Front Aging Neurosci Date: 2022-07-11 Impact factor: 5.702