| Literature DB >> 32861017 |
Sha Xiong1, Zhongjun Li2, Yao Liu1, Qun Wang1, Jingshan Luo1, Xiaojia Chen3, Zhongjian Xie2, Yuan Zhang4, Han Zhang5, Tongkai Chen6.
Abstract
The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capable of achieving satisfactory biocompatibility and biosafety with excellent anti-Parkinsonian efficacy, making it ideal for clinical applications.Entities:
Keywords: Black phosphorus nanosheets; Blood-brain barrier; Brain targeting; Drug delivery; Lactoferrin
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Year: 2020 PMID： 32861017 DOI： 10.1016/j.biomaterials.2020.120339
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479