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Literature DB >> 32860591

GABA_B Receptors: Anxiety and Mood Disorders.

Daniela Felice^1,2, John F Cryan^3,4, Olivia F O'Leary^5,6.

Abstract

Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, acts at the ionotropic GABAA and GABAC receptors, and the metabotropic GABAB receptor. This chapter summarizes the studies that have investigated the role of the GABAB receptor in stress-related psychiatric disorders including anxiety and mood disorders. Overall, clinical and preclinical evidences strongly suggest that the GABAB receptor is a therapeutic candidate for depression and anxiety disorders. However, the clinical development of GABAB receptor-based drugs to treat these disorders has been hampered by their potential side-effects, particularly those of agonists. Nevertheless, the discovery of novel GABAB receptor allosteric modulators, and increasing understanding of the influence of specific intracellular GABAB receptor-associated proteins on GABAB receptor activity, may now pave the way towards GABAB receptor therapeutics in the treatment of mood and anxiety disorders.

Entities: Chemical

Keywords: Anxiety; Depression; GABAB receptor; Hippocampal neurogenesis; Mood; Stress; Stress resilience

Mesh：

Substances：

Year: 2022 PMID： 32860591 DOI： 10.1007/7854_2020_171

Source DB: PubMed Journal: Curr Top Behav Neurosci ISSN： 1866-3370

105 in total

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Authors: J ALTMAN
Journal: Exp Neurol Date: 1962-04 Impact factor: 5.330

2. Are new neurons formed in the brains of adult mammals?

Authors: J ALTMAN
Journal: Science Date: 1962-03-30 Impact factor: 47.728

Review 3. Molecular structure and physiological functions of GABA(B) receptors.

Authors: Bernhard Bettler; Klemens Kaupmann; Johannes Mosbacher; Martin Gassmann
Journal: Physiol Rev Date: 2004-07 Impact factor: 37.312

4. Epigenetic regulation of dorsal raphe GABA(B1a) associated with isolation-induced abnormal responses to social stimulation in mice.

Authors: Ryota Araki; Yosuke Hiraki; Shoji Nishida; Nobuyuki Kuramoto; Kinzo Matsumoto; Takeshi Yabe
Journal: Neuropharmacology Date: 2015-09-11 Impact factor: 5.250

Review 5. The potential efficacy of GABA_B antagonists in depression.

Authors: Robert C Alexander
Journal: Curr Opin Pharmacol Date: 2017-08-11 Impact factor: 5.547

Review 6. Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence.

Authors: N Andrews; S E File
Journal: Psychopharmacology (Berl) Date: 1993 Impact factor: 4.530

7. Effects of baclofen on anxiety, sexual motivation, and olfactory perception in male mice in different psychoemotional states.

Authors: A V Amikishieva; S N Semendyaeva
Journal: Neurosci Behav Physiol Date: 2007-11

GABA_B Receptors: Anxiety and Mood Disorders.

1. Autoradiographic study of degenerative and regenerative proliferation of neuroglia cells with tritiated thymidine.

2. Are new neurons formed in the brains of adult mammals?

Review 3. Molecular structure and physiological functions of GABA(B) receptors.

4. Epigenetic regulation of dorsal raphe GABA(B1a) associated with isolation-induced abnormal responses to social stimulation in mice.

Review 5. The potential efficacy of GABA_B antagonists in depression.

Review 6. Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence.

7. Effects of baclofen on anxiety, sexual motivation, and olfactory perception in male mice in different psychoemotional states.

Review 8. CGP7930: a positive allosteric modulator of the GABAB receptor.

Review 9. Efficacy and tolerability of baclofen in substance use disorders: a systematic review.

10. Effect of baclofen, a GABAB-agonist, on forced swimming-induced immobility in mice.

Review 1. Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review.

GABAB Receptors: Anxiety and Mood Disorders.

1. Autoradiographic study of degenerative and regenerative proliferation of neuroglia cells with tritiated thymidine.

2. Are new neurons formed in the brains of adult mammals?

Review 3. Molecular structure and physiological functions of GABA(B) receptors.

4. Epigenetic regulation of dorsal raphe GABA(B1a) associated with isolation-induced abnormal responses to social stimulation in mice.

Review 5. The potential efficacy of GABAB antagonists in depression.

Review 6. Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence.

7. Effects of baclofen on anxiety, sexual motivation, and olfactory perception in male mice in different psychoemotional states.

Review 8. CGP7930: a positive allosteric modulator of the GABAB receptor.

Review 9. Efficacy and tolerability of baclofen in substance use disorders: a systematic review.

10. Effect of baclofen, a GABAB-agonist, on forced swimming-induced immobility in mice.

Review 1. Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review.

GABA_B Receptors: Anxiety and Mood Disorders.

Review 5. The potential efficacy of GABA_B antagonists in depression.