Literature DB >> 32858446

Gating and calcium-sensing mechanisms of TRPA1 channels revealed.

Sebastian E Brauchi1, Brad S Rothberg2.   

Abstract

Novel structures of the human TRPA1 channel were determined in the presence of the agonist iodoacetamide and the antagonist A-967079, to reveal the open and closed states of the channel, respectively. The structures further revealed the location of Ca2+ modulatory site that is likely conserved among several TRP subgroups.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Calcium; Channel; Mustard; Pain; Sensory; TRP

Mesh：

Substances：

Year:  2020        PMID： 32858446      PMCID： PMC7530115          DOI： 10.1016/j.ceca.2020.102278

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  10 in total

1.  A role of the transient receptor potential domain of vanilloid receptor I in channel gating.

Authors:  Nuria García-Sanz; Pierluigi Valente; Ana Gomis; Asia Fernández-Carvajal; Gregorio Fernández-Ballester; Felix Viana; Carlos Belmonte; Antonio Ferrer-Montiel
Journal:  J Neurosci       Date:  2007-10-24       Impact factor: 6.167

Review 2.  How membrane proteins sense voltage.

Authors:  Francisco Bezanilla
Journal:  Nat Rev Mol Cell Biol       Date:  2008-04       Impact factor: 94.444

3.  Structure of the TRPA1 ion channel suggests regulatory mechanisms.

Authors:  Candice E Paulsen; Jean-Paul Armache; Yuan Gao; Yifan Cheng; David Julius
Journal:  Nature       Date:  2015-07-22       Impact factor: 49.962

4.  Structural insights into TRPM8 inhibition and desensitization.

Authors:  Melinda M Diver; Yifan Cheng; David Julius
Journal:  Science       Date:  2019-09-05       Impact factor: 47.728

5.  Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.

Authors:  Bernd Nilius; Jean Prenen; Joost G J Hoenderop; Rudi Vennekens; Susan Hoefs; A Freek Weidema; Guy Droogmans; René J M Bindels
Journal:  J Biol Chem       Date:  2002-06-19       Impact factor: 5.157

6.  The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.

Authors:  Yuanyuan Y Wang; Rui B Chang; Hang N Waters; David D McKemy; Emily R Liman
Journal:  J Biol Chem       Date:  2008-09-05       Impact factor: 5.157

Review 7.  TRPA1 as a drug target--promise and challenges.

Authors:  Jun Chen; David H Hackos
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2015-02-03       Impact factor: 3.000

8.  Irritant-evoked activation and calcium modulation of the TRPA1 receptor.

Authors:  Jianhua Zhao; John V Lin King; Candice E Paulsen; Yifan Cheng; David Julius
Journal:  Nature       Date:  2020-07-08       Impact factor: 49.962

9.  Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function.

Authors:  Jingjing Duan; Jian Li; Gui-Lan Chen; Yan Ge; Jieyu Liu; Kechen Xie; Xiaogang Peng; Wei Zhou; Jianing Zhong; Yixing Zhang; Jie Xu; Changhu Xue; Bo Liang; Lan Zhu; Wei Liu; Cheng Zhang; Xiao-Li Tian; Jianbin Wang; David E Clapham; Bo Zeng; Zongli Li; Jin Zhang
Journal:  Sci Adv       Date:  2019-07-24       Impact factor: 14.136

10.  Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.

Authors:  Zhe Zhang; Balázs Tóth; Andras Szollosi; Jue Chen; László Csanády
Journal:  Elife       Date:  2018-05-10       Impact factor: 8.140
  10 in total

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