Comparison of efficacy and tolerance of different oral doses of torasemide and furosemide in patients with advanced chronic renal failure.

In a double-blind, randomised group comparative study the efficacy of daily oral administration of 100 mg and 200 mg torasemide (1-isopropyl-3-([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea) were compared with that of 250 mg furosemide over 2 weeks in patients with advanced chronic renal failure, who had been pretreated with a maintenance therapy of 500 mg furosemide per day. Of the 19 patients 7 had been allocated strictly at random to 100 mg torasemide, 6 to 200 mg torasemide and 6 patients to 250 mg furosemide. The volume excretion after administration of 200 mg torasemide was significantly higher than after administration of 250 mg furosemide and non-significantly higher than after 100 mg torasemide. In comparison with baseline values under pretreatment with 500 mg furosemide there was a slight reduction of fluid and sodium excretion in the 100 mg torasemide group and a clear reduction in the 250 mg furosemide group. In contrast, in the 200 mg torasemide group excretion of fluid and sodium increased. The tolerance was good in all 3 groups.

RCT Entities:   Population Interventions Outcomes