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Literature DB >> 32857878

Thrombosis in COVID-19.

Thomas C Hanff^1,2, Amir M Mohareb^3,4, Jay Giri¹, Jordana B Cohen^2,5, Julio A Chirinos¹.

Abstract

Thrombotic complications are frequent in COVID-19 and contribute significantly to mortality and morbidity. We review several mechanisms of hypercoagulability in sepsis that may be upregulated in COVID-19. These include immune-mediated thrombotic mechanisms, complement activation, macrophage activation syndrome, antiphospholipid antibody syndrome, hyperferritinemia, and renin-angiotensin system dysregulation. We highlight biomarkers within each pathway with potential prognostic value in COVID-19. Lastly, recent observational studies have evaluated a role for the expanded use of therapeutic anticoagulation in COVID-19. We review strengths and weaknesses of these studies, and we also discuss the hypothetical benefit and anticipated challenges of fibrinolytic therapy in COVID-19.

Entities: Disease

Mesh：

Substances：
Anticoagulants
Ferritins

Year: 2020 PMID： 32857878 PMCID： PMC7674272 DOI： 10.1002/ajh.25982

Source DB: PubMed Journal: Am J Hematol ISSN： 0361-8609 Impact factor: 10.047

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Journal: JAMA Cardiol Date: 2020-07-01 Impact factor: 14.676

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Review 9. COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?

Authors: Serena Colafrancesco; Cristiano Alessandri; Fabrizio Conti; Roberta Priori
Journal: Autoimmun Rev Date: 2020-05-05 Impact factor: 9.754

10. COVID-19 Does Not Lead to a "Typical" Acute Respiratory Distress Syndrome.

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70 in total

Review 1. Awaiting a cure for COVID-19: therapeutic approach in patients with different severity levels of COVID-19.

Authors: Gaetano Alfano; Niccolò Morisi; Monica Frisina; Annachiara Ferrari; Francesco Fontana; Roberto Tonelli; Erica Franceschini; Marianna Meschiari; Gabriele Donati; Giovanni Guaraldi
Journal: Infez Med Date: 2022-03-01

2. Endovascular revascularization of an occluded persistent sciatic artery for chronic limb-threatening ischemia in a patient with Coronavirus Disease 2019.

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Journal: Int Immunopharmacol Date: 2021-05-11 Impact factor: 5.714

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Authors: Joshua A Rushakoff; Alexander Polyak; Jayne Caron; Kristin Parrinella; Reza Salabat; Melissa Wong; Dominic Emerson
Journal: J Card Surg Date: 2021-05-11 Impact factor: 1.778