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Literature DB >> 32857169

hPSC-derived organoids: models of human development and disease.

Abstract

Organoids derived from human pluripotent stem cells (hPSCs) have emerged as important models for investigating human-specific aspects of development and disease. Here we discuss hPSC-derived organoids through the lens of development-highlighting how stages of human development align with the development of hPSC-derived organoids in the tissue culture dish. Using hPSC-derived lung and intestinal organoids as examples, we discuss the value and application of such systems for understanding human biology, as well as strategies for enhancing organoid complexity and maturity.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Cell signaling; Development; Disease modeling; Human; Organoids; Stem cells

Year: 2020 PMID： 32857169 PMCID： PMC7914270 DOI： 10.1007/s00109-020-01969-w

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

122 in total

1. Quality control guidelines for clinical-grade human induced pluripotent stem cell lines.

Authors: Stephen Sullivan; Glyn N Stacey; Chihiro Akazawa; Naoki Aoyama; Ricardo Baptista; Patrick Bedford; Annelise Bennaceur Griscelli; Amit Chandra; Ngaire Elwood; Mathilde Girard; Shin Kawamata; Tadaaki Hanatani; Theodoros Latsis; Stephen Lin; Tenneille E Ludwig; Tamara Malygina; Amanda Mack; Joanne C Mountford; Scott Noggle; Lygia V Pereira; Jack Price; Michael Sheldon; Alok Srivastava; Harald Stachelscheid; Shaji R Velayudhan; Natalie J Ward; Marc L Turner; Jacqueline Barry; Jihwan Song
Journal: Regen Med Date: 2018-09-12 Impact factor: 3.806

2. Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.

Authors: Jhansi L Leslie; Sha Huang; Judith S Opp; Melinda S Nagy; Masayuki Kobayashi; Vincent B Young; Jason R Spence
Journal: Infect Immun Date: 2014-10-13 Impact factor: 3.441

3. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.

Authors: Jian Hui Low; Pin Li; Elaine Guo Yan Chew; Bingrui Zhou; Keiichiro Suzuki; Tian Zhang; Michelle Mulan Lian; Meng Liu; Emi Aizawa; Concepcion Rodriguez Esteban; Kylie Su Mei Yong; Qingfeng Chen; Josep M Campistol; Mingliang Fang; Chiea Chuen Khor; Jia Nee Foo; Juan Carlos Izpisua Belmonte; Yun Xia
Journal: Cell Stem Cell Date: 2019-07-11 Impact factor: 24.633

4. Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells.

Authors: Takanori Takebe; Keisuke Sekine; Masaki Kimura; Emi Yoshizawa; Satoru Ayano; Masaru Koido; Shizuka Funayama; Noriko Nakanishi; Tomoko Hisai; Tatsuya Kobayashi; Toshiharu Kasai; Rina Kitada; Akira Mori; Hiroaki Ayabe; Yoko Ejiri; Naoki Amimoto; Yosuke Yamazaki; Shimpei Ogawa; Momotaro Ishikawa; Yasujiro Kiyota; Yasuhiko Sato; Kohei Nozawa; Satoshi Okamoto; Yasuharu Ueno; Hideki Taniguchi
Journal: Cell Rep Date: 2017-12-05 Impact factor: 9.423

5. Differentiated human stem cells resemble fetal, not adult, β cells.

Authors: Sinisa Hrvatin; Charles W O'Donnell; Francis Deng; Jeffrey R Millman; Felicia Walton Pagliuca; Philip DiIorio; Alireza Rezania; David K Gifford; Douglas A Melton
Journal: Proc Natl Acad Sci U S A Date: 2014-02-10 Impact factor: 11.205

6. Long-term culture of genome-stable bipotent stem cells from adult human liver.

Authors: Meritxell Huch; Helmuth Gehart; Ruben van Boxtel; Karien Hamer; Francis Blokzijl; Monique M A Verstegen; Ewa Ellis; Martien van Wenum; Sabine A Fuchs; Joep de Ligt; Marc van de Wetering; Nobuo Sasaki; Susanne J Boers; Hans Kemperman; Jeroen de Jonge; Jan N M Ijzermans; Edward E S Nieuwenhuis; Ruurdtje Hoekstra; Stephen Strom; Robert R G Vries; Luc J W van der Laan; Edwin Cuppen; Hans Clevers
Journal: Cell Date: 2014-12-18 Impact factor: 41.582

7. Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids.

Authors: Meghan M Capeling; Michael Czerwinski; Sha Huang; Yu-Hwai Tsai; Angeline Wu; Melinda S Nagy; Benjamin Juliar; Nambirajan Sundaram; Yang Song; Woojin M Han; Shuichi Takayama; Eben Alsberg; Andres J Garcia; Michael Helmrath; Andrew J Putnam; Jason R Spence
Journal: Stem Cell Reports Date: 2019-01-03 Impact factor: 7.294

8. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.

Authors: Stuart M Chambers; Christopher A Fasano; Eirini P Papapetrou; Mark Tomishima; Michel Sadelain; Lorenz Studer
Journal: Nat Biotechnol Date: 2009-03-01 Impact factor: 54.908

9. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.

Authors: J Gray Camp; Farhath Badsha; Marta Florio; Sabina Kanton; Tobias Gerber; Michaela Wilsch-Bräuninger; Eric Lewitus; Alex Sykes; Wulf Hevers; Madeline Lancaster; Juergen A Knoblich; Robert Lachmann; Svante Pääbo; Wieland B Huttner; Barbara Treutlein
Journal: Proc Natl Acad Sci U S A Date: 2015-12-07 Impact factor: 11.205

10. In Vitro Induction and In Vivo Engraftment of Lung Bud Tip Progenitor Cells Derived from Human Pluripotent Stem Cells.

Authors: Alyssa J Miller; David R Hill; Melinda S Nagy; Yoshiro Aoki; Briana R Dye; Alana M Chin; Sha Huang; Felix Zhu; Eric S White; Vibha Lama; Jason R Spence
Journal: Stem Cell Reports Date: 2017-12-14 Impact factor: 7.765

4 in total