| Literature DB >> 32856656 |
Si Si Liew1, Chengwu Zhang, Jie Zhang, Hongyan Sun, Lin Li, Shao Q Yao.
Abstract
A versatile strategy for the intracellular delivery of functional proteins/antibodies was developed using N-terminal site-specific modification. Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed complementing N-terminal site-specific modification with lysine labeling. Upon successful cytosolic uptake, the prodrug showed reactive oxygen species (ROS)-dependent targeted cancer therapy.Entities:
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Year: 2020 PMID： 32856656 DOI： 10.1039/d0cc04728g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222