| Literature DB >> 32854857 |
Edward J Calabrese1, Mark P Mattson2, Gaurav Dhawan3, Rachna Kapoor4, Vittorio Calabrese5, James Giordano6.
Abstract
This review describes neuroprotective effects mediated by pre- and post-conditioning-induced processes that act via the quantitative features of the hormetic dose response. These lead to the development of acquired resilience that can protect neuronal systems from endogenous and exogenous stresses and insult. Particular attention is directed to issues of dose optimization, inter-individual variation, and potential ways to further study and employ hormetic-based preconditioning approaches in medical and public health efforts to treat and prevent neurodegenerative disease.Entities:
Keywords: Aging; Alzheimer's disease; Biphasic dose response; Dose response; Hormesis; Neurodegenerative disease; Parkinson's disease; Preconditioning
Year: 2020 PMID: 32854857 DOI: 10.1016/bs.irn.2020.03.024
Source DB: PubMed Journal: Int Rev Neurobiol ISSN: 0074-7742 Impact factor: 3.230