| Literature DB >> 3285292 |
Abstract
The hamster papovavirus (HaPV) is a polyomavirus isolated from hair follicle tumor arising spontaneously in newborn hamsters which can also induce lymphoma and leukemia. This tissue specificity displayed in vivo can be bypassed in vitro since HaPV carries the full transforming properties of a polyomavirus (immortalization and transformation). We report here the phenotypic characterization of cells that were selected as immortalized or transformed and express constitutively the HaPV early genes. The viral genome is integrated in the host DNA and the early region is actively transcribed and translated.Entities:
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Year: 1988 PMID: 3285292
Source DB: PubMed Journal: Oncogene ISSN: 0950-9232 Impact factor: 9.867