Julie Oniszczuk1,2, Anissa Moktefi2,3, Aude Mausoleo1,2, Nicolas Pallet4, Stephanie Malard-Castagnet5, Slim Fourati6,7, Khalil El Karoui1,2, Dil Sahali1,2, Thomas Stehlé1,2, Anna Boueilh1,2, Marie-Christine Verpont8,9, Marie Matignon1,2, David Buob10, Philippe Grimbert1,2, Vincent Audard1,2. 1. Assistance Publique des Hôpitaux de Paris, Hôpitaux Universitaires Henri-Mondor, Service de Néphrologie et Transplantation, Centre de Référence Maladie Rare "Syndrome Néphrotique Idiopathique", Fédération Hospitalo-Universitaire, Innovative Therapy for Immune Disorders, Créteil, France. 2. Univ Paris Est Créteil, Institut National de la Santé et de la Recherche Médicale (INSERM) U955, Institut Mondor de Recherche Biomédicale (IMRB), Créteil, France. 3. Assistance Publique des Hôpitaux de Paris, Hôpitaux Universitaires Henri-Mondor, Département de Pathologie, Créteil, France. 4. Assistance Publique des Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. 5. Assistance Publique des Hôpitaux de Paris, Hôpital saint Louis, Laboratoire d'Immunologie et d'Histocompatibilité, Paris, France. 6. Assistance Publique des Hôpitaux de Paris, Hôpitaux Universitaires Henri-Mondor, Département Prévention, Diagnostic et Traitement des Infections, Centre National de Référence des Hépatites Virales B, C et Delta, Créteil, France. 7. Univ Paris Est Créteil, INSERM, IMRB, Equipe 18, Créteil, France. 8. INSERM, UMRS 1155, Hôpital Tenon, Paris, France. 9. Sorbonne Université, Plateforme d'Imagerie et de Cytométrie, UMRS 1155, Paris, France. 10. Sorbonne Université, Assistance Publique des Hôpitaux de Paris, Service d'Anatomie et Cytologie Pathologiques, INSERM, UMRS 1155, Hôpital Tenon, Paris, France.
Abstract
BACKGROUND: There is compelling evidence that renal complications in a native kidney are a major concern in patients infected with severe acute respiratory syndrome coronavirus 2, the causal agent of coronavirus disease 2019 (COVID-19). The spectrum of renal lesions observed on renal grafts in this context remains to be determined. METHODS: We report the case of a renal transplant recipient with non-severe COVID-19, who subsequently developed nephrotic syndrome associated with acute renal injury. RESULTS: Renal biopsy demonstrated focal and segmental glomerulosclerosis lesions classified as not otherwise specified histological variant. Genotyping for 2 risk alleles of the apolipoprotein L1 gene demonstrated that the donor was homozygous for the G2/G2 genotype. CONCLUSIONS: In renal transplant patients receiving kidneys from donors with high-risk apolipoprotein L1 variants, COVID-19 may promote acute glomerular injury in the form of focal and segmental glomerulosclerosis.
BACKGROUND: There is compelling evidence that renal complications in a native kidney are a major concern in patientsinfected with severe acute respiratory syndrome coronavirus 2, the causal agent of coronavirus disease 2019 (COVID-19). The spectrum of renal lesions observed on renal grafts in this context remains to be determined. METHODS: We report the case of a renal transplant recipient with non-severe COVID-19, who subsequently developed nephrotic syndrome associated with acute renal injury. RESULTS: Renal biopsy demonstrated focal and segmental glomerulosclerosis lesions classified as not otherwise specified histological variant. Genotyping for 2 risk alleles of the apolipoprotein L1 gene demonstrated that the donor was homozygous for the G2/G2 genotype. CONCLUSIONS: In renal transplant patients receiving kidneys from donors with high-risk apolipoprotein L1 variants, COVID-19 may promote acute glomerular injury in the form of focal and segmental glomerulosclerosis.
Authors: Emily Daniel; Miroslav Sekulic; Satoru Kudose; Christine Kubin; Xiaoyi Ye; Katayoon Shayan; Ankita Patel; David J Cohen; Lloyd E Ratner; Dominick Santoriello; M Barry Stokes; Glen S Markowitz; Marcus R Pereira; Vivette D D'Agati; Ibrahim Batal Journal: Am J Transplant Date: 2021-09-03 Impact factor: 9.369