Marie O Collet1,2, Ingrid Egerod1,2, Thordis Thomsen3, Jørn Wetterslev4, Theis Lange5, Bjørn H Ebdrup6,7, Anders Perner1,2. 1. Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark. 2. Centre for Research in Intensive Care, Copenhagen, Denmark. 3. Herlev ACES - Herlev Anaesthesia Critical and Emergency Care Science Unit, Department of Anaesthesia, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark. 4. Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Denmark. 5. Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark. 6. Center for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre, Glostrup, Denmark. 7. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Abstract
PURPOSE: To describe the incidence of and risk factors for impaired cognitive function in intensive care unit (ICU) survivors. We hypothesized that age, severity of illness, and days in coma, delirium, mechanical ventilation in the ICU would be associated with impaired cognitive function. METHODS: We included all adults, alive 6 months after acute admission to one of the 24 Danish ICUs participating in the AID-ICU cohort study. Trained professionals assessed cognitive function in patients' homes or in outpatient clinics using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) 6 months after ICU admission. Potential risk factors for cognitive impairment were analyzed with linear regression models. RESULTS: In total, 237 ICU patients were alive 6 months after ICU admission and did not meet the exclusion criteria. A total of 106 patients completed the cognitive assessment. The median RBANS global cognitive score was 76 (interquartile range, 62-91), and 52% had a global cognitive score 1.5 SD below the normative mean and 36% displayed a global cognitive score 2 SD below the normative mean, similar to that of Alzheimer's disease. Higher age was associated with poorer RBANS global cognitive score (estimate -0.35 [95% confidence interval -0.63 to -0.07] per year). CONCLUSIONS: In this multicenter study of adult ICU survivors, cognitive impairment was frequent and severe in those assessed at 6 months. Higher age was a risk factor for cognitive impairment, but events related to the ICU stay were not associated with poorer cognitive performance at 6 months.
PURPOSE: To describe the incidence of and risk factors for impaired cognitive function in intensive care unit (ICU) survivors. We hypothesized that age, severity of illness, and days in coma, delirium, mechanical ventilation in the ICU would be associated with impaired cognitive function. METHODS: We included all adults, alive 6 months after acute admission to one of the 24 Danish ICUs participating in the AID-ICU cohort study. Trained professionals assessed cognitive function in patients' homes or in outpatient clinics using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) 6 months after ICU admission. Potential risk factors for cognitive impairment were analyzed with linear regression models. RESULTS: In total, 237 ICU patients were alive 6 months after ICU admission and did not meet the exclusion criteria. A total of 106 patients completed the cognitive assessment. The median RBANS global cognitive score was 76 (interquartile range, 62-91), and 52% had a global cognitive score 1.5 SD below the normative mean and 36% displayed a global cognitive score 2 SD below the normative mean, similar to that of Alzheimer's disease. Higher age was associated with poorer RBANS global cognitive score (estimate -0.35 [95% confidence interval -0.63 to -0.07] per year). CONCLUSIONS: In this multicenter study of adult ICU survivors, cognitive impairment was frequent and severe in those assessed at 6 months. Higher age was a risk factor for cognitive impairment, but events related to the ICU stay were not associated with poorer cognitive performance at 6 months.
Authors: Ana Costas-Carrera; Marta Mónica Sánchez-Rodríguez; Silvia Cañizares; Antonio Ojeda; Inés Martín-Villalba; Mireia Primé-Tous; Manuel Arturo Rodríguez-Rey; Xavier Segú; Francisco Valdesoiro-Pulido; Roger Borras; Josep Maria Peri; Eduard Vieta Journal: Brain Behav Immun Health Date: 2022-02-07