Toshimitsu Shiozawa1, Yutaro Kikuchi2,3, Tetsuji Wakabayashi1, Kenichi Matsuo1,2, Yuki Takahashi1, Kuniya Tanaka4,5,6. 1. Department of General and Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, 227-8501, Japan. 2. Department of Surgery, Division of Hepato-biliary-pancreatic Surgery, Teikyo University Chiba Medical Center, Chiba, Japan. 3. Departments of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan. 4. Department of General and Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, 227-8501, Japan. u1792ts235@med.showa-u.ac.jp. 5. Department of Surgery, Division of Hepato-biliary-pancreatic Surgery, Teikyo University Chiba Medical Center, Chiba, Japan. u1792ts235@med.showa-u.ac.jp. 6. Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan. u1792ts235@med.showa-u.ac.jp.
Abstract
INTRODUCTION: For many kinds of cancer, body composition and immunonutritional status have been reported to influence postoperative outcome. We assessed their impact on short- and long-term outcome in patients with colorectal liver metastases who underwent 2-stage liver resections. METHODS: Short- and long-term outcomes for 47 patients with 2-stage hepatectomies were assessed retrospectively in terms of data obtained before preoperative chemotherapy, before the first hepatectomy, and before the second hepatectomy. RESULTS: Although immunonutritional status and body composition did not affect short-term outcome, high intramuscular fat content before the second hepatectomy was a poor prognostic factor for overall survival (HR, 5.829; 95% CI, 1.611-21.090; p = 0.007) and for recurrence-free survival (HR, 2.787; 95% CI, 1.301-5.973; p = 0.008). Patients with high intramuscular fat before the second hepatectomy also showed shorter intervals from recurrence to treatment failure. CONCLUSION: Intramuscular fat before the second hepatectomy is an important negative prognosticator in 2-stage liver resection for colorectal liver metastases.
INTRODUCTION: For many kinds of cancer, body composition and immunonutritional status have been reported to influence postoperative outcome. We assessed their impact on short- and long-term outcome in patients with colorectal liver metastases who underwent 2-stage liver resections. METHODS: Short- and long-term outcomes for 47 patients with 2-stage hepatectomies were assessed retrospectively in terms of data obtained before preoperative chemotherapy, before the first hepatectomy, and before the second hepatectomy. RESULTS: Although immunonutritional status and body composition did not affect short-term outcome, high intramuscular fat content before the second hepatectomy was a poor prognostic factor for overall survival (HR, 5.829; 95% CI, 1.611-21.090; p = 0.007) and for recurrence-free survival (HR, 2.787; 95% CI, 1.301-5.973; p = 0.008). Patients with high intramuscular fat before the second hepatectomy also showed shorter intervals from recurrence to treatment failure. CONCLUSION: Intramuscular fat before the second hepatectomy is an important negative prognosticator in 2-stage liver resection for colorectal liver metastases.
Authors: K Tanaka; K Matsuo; T Murakami; D Kawaguchi; Y Hiroshima; K Koda; I Endo; Y Ichikawa; M Taguri; M Tanabe Journal: Eur J Surg Oncol Date: 2015-02-10 Impact factor: 4.424
Authors: Peter D Peng; Mark G van Vledder; Susan Tsai; Mechteld C de Jong; Martin Makary; Julie Ng; Barish H Edil; Christopher L Wolfgang; Richard D Schulick; Michael A Choti; Ihab Kamel; Timothy M Pawlik Journal: HPB (Oxford) Date: 2011-03-29 Impact factor: 3.647
Authors: Andreas A Schnitzbauer; Sven A Lang; Holger Goessmann; Silvio Nadalin; Janine Baumgart; Stefan A Farkas; Stefan Fichtner-Feigl; Thomas Lorf; Armin Goralcyk; Rüdiger Hörbelt; Alexander Kroemer; Martin Loss; Petra Rümmele; Marcus N Scherer; Winfried Padberg; Alfred Königsrainer; Hauke Lang; Aiman Obed; Hans J Schlitt Journal: Ann Surg Date: 2012-03 Impact factor: 12.969
Authors: Dennis A Wicherts; Rafael Miller; Robbert J de Haas; Georgia Bitsakou; Eric Vibert; Luc-Antoine Veilhan; Daniel Azoulay; Henri Bismuth; Denis Castaing; René Adam Journal: Ann Surg Date: 2008-12 Impact factor: 12.969
Authors: N Harimoto; K Shirabe; Y-I Yamashita; T Ikegami; T Yoshizumi; Y Soejima; T Ikeda; Y Maehara; A Nishie; T Yamanaka Journal: Br J Surg Date: 2013-10 Impact factor: 6.939