Literature DB >> 32847819

Cytokine storm release syndrome and the prospects for immunotherapy with COVID-19, part 4: The role of JAK inhibition: Posted February 10, 2021.

Leonard H Calabrese1, Tiphaine Lenfant2,3,4, Cassandra Calabrese5.   

Abstract

This review focuses on an alternative strategy utilizing small molecules to inhibit a key signal-transduction pathway, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The JAK-STAT pathway mediates biologic activity for a large number of inflammatory cytokines and mediators.
Copyright © 2021 The Cleveland Clinic Foundation. All Rights Reserved.

Entities:  

Year:  2021        PMID： 32847819     DOI： 10.3949/ccjm.87a.ccc060

Source DB:  PubMed          Journal:  Cleve Clin J Med        ISSN： 0891-1150            Impact factor:   2.321


  4 in total

1.  The Intersection of COVID-19 and Autoimmunity: What is Our Current Understanding?

Authors:  N Winchester; C Calabrese; L H Calabrese
Journal:  Pathog Immun       Date:  2021-03-08

2.  Real-Life Effectiveness and Safety of Baricitinib as Adjunctive to Standard-of-Care Treatment in Hospitalized Patients With Severe Coronavirus Disease 2019.

Authors:  Nikolaos Tziolos; Emmanouil Karofylakis; Ioannis Grigoropoulos; Pinelopi Kazakou; Emmanouil Koullias; Athina Savva; Hariklia Kranidioti; Aimilia Pelekanou; Anna Boulouta; Maria Pirounaki; Sotirios Tsiodras; Georgios Georgiopoulos; Dimitrios T Boumpas; Dimitra Kavatha; Konstantinos Thomas; Dimitrios Vassilopoulos; Anastasia Antoniadou
Journal:  Open Forum Infect Dis       Date:  2021-11-22       Impact factor: 3.835

Review 3.  Neurological complications associated with Covid-19; molecular mechanisms and therapeutic approaches.

Authors:  Mohammad Mahboubi Mehrabani; Mohammad Sobhan Karvandi; Pedram Maafi; Mohammad Doroudian
Journal:  Rev Med Virol       Date:  2022-02-09       Impact factor: 11.043

Review 4.  The signal pathways and treatment of cytokine storm in COVID-19.

Authors:  Lan Yang; Xueru Xie; Zikun Tu; Jinrong Fu; Damo Xu; Yufeng Zhou
Journal:  Signal Transduct Target Ther       Date:  2021-07-07
  4 in total

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