Literature DB >> 3284758

Plasmodium falciparum: cloning by single-erythrocyte micromanipulation and heterogeneity in vitro.

A M Oduola1, N F Weatherly, J H Bowdre, R E Desjardins.   

Abstract

Natural isolates of Plasmodium falciparum represent a genetically heterogeneous population of parasites. To obtain stable strains of the parasites for long term experiments, a rapid and definitive method of cloning was developed using micropipets and a micromanipulator. Homogeneous parasite clones prepared by this technique were characterized and compared with the parent isolates during 4 years of continuous culture. The process of phenotypic dominance and selection of drug resistance which occur in nature was also simulated in vitro by evaluating population dynamics of two cocultured isolates of P. falciparum.

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Year:  1988        PMID： 3284758     DOI： 10.1016/0014-4894(88)90053-7

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN： 0014-4894            Impact factor:   2.011


  43 in total

1.  Efficacy of proton pump inhibitor drugs against Plasmodium falciparum in vitro and their probable pharmacophores.

Authors:  Michael A Riel; Dennis E Kyle; Apurba K Bhattacharjee; Wilbur K Milhous
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

2.  Plasmodium falciparum: a simplified technique for obtaining singly infected erythrocytes.

Authors:  Manoj K Puthia; Kevin S W Tan
Journal:  Parasitol Res       Date:  2004-12-23       Impact factor: 2.289

3.  Assessment of malaria in vitro drug combination screening and mixed-strain infections using the malaria Sybr green I-based fluorescence assay.

Authors:  Edgie-Mark A Co; Richard A Dennull; Drew D Reinbold; Norman C Waters; Jacob D Johnson
Journal:  Antimicrob Agents Chemother       Date:  2009-04-06       Impact factor: 5.191

4.  Proteome analysis of new antimalarial endoperoxide against Plasmodium falciparum.

Authors:  Nagwa S M Aly; Akiko Hiramoto; Hitomi Sanai; Osamu Hiraoka; Kazuyuki Hiramoto; Hiroyuki Kataoka; Jin-Ming Wu; Araki Masuyama; Masatomo Nojima; Satoru Kawai; Hye-Sook Kim; Yusuke Wataya
Journal:  Parasitol Res       Date:  2007-02-02       Impact factor: 2.289

5.  Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria.

Authors:  C T Happi; G O Gbotosho; O A Folarin; A Sowunmi; O M Bolaji; B A Fateye; D E Kyle; W Milhous; D F Wirth; A M J Oduola
Journal:  Parasitol Res       Date:  2006-07-28       Impact factor: 2.289

6.  Antimalarial activities of new pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives.

Authors:  Jian Guan; Quan Zhang; Michael O'Neil; Nicanor Obaldia; Arba Ager; Lucia Gerena; Ai J Lin
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

7.  Potentiation of the antimalarial agent rufigallol.

Authors:  R W Winter; K A Cornell; L L Johnson; M Ignatushchenko; D J Hinrichs; M K Riscoe
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

8.  Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.

Authors:  S Gassis; P K Rathod
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

9.  Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.

Authors:  P K Rathod; S Reshmi
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

10.  Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity.

Authors:  C A Bell; M Cory; T A Fairley; J E Hall; R R Tidwell
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191
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