Literature DB >> 32845256

Avobenzone incorporation in a diverse range of Ru(II) scaffolds produces potent potential antineoplastic agents.

Raphael T Ryan1, Dmytro Havrylyuk, Kimberly C Stevens, L Henry Moore, Doo Young Kim, Jessica S Blackburn, David K Heidary, John P Selegue, Edith C Glazer.   

Abstract

Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.

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Year:  2020        PMID： 32845256      PMCID： PMC8607750          DOI： 10.1039/d0dt02016h

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.569


  30 in total

1.  New RuII Scaffold for Photoinduced Ligand Release with Red Light in the Photodynamic Therapy (PDT) Window.

Authors:  Lauren M Loftus; Kathlyn F Al-Afyouni; Claudia Turro
Journal:  Chemistry       Date:  2018-07-20       Impact factor: 5.236

2.  A Multi-action and Multi-target RuII -PtIV Conjugate Combining Cancer-Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers.

Authors:  Johannes Karges; Thirumal Yempala; Mickaël Tharaud; Dan Gibson; Gilles Gasser
Journal:  Angew Chem Int Ed Engl       Date:  2020-03-11       Impact factor: 15.336

3.  Note of Caution for the Aqueous Behaviour of Metal-Based Drug Candidates.

Authors:  Anna Notaro; Gilles Gasser; Annie Castonguay
Journal:  ChemMedChem       Date:  2020-01-21       Impact factor: 3.466

Review 4.  Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

Authors:  Sreekanth Thota; Daniel A Rodrigues; Debbie C Crans; Eliezer J Barreiro
Journal:  J Med Chem       Date:  2018-02-26       Impact factor: 7.446

5.  Structure-activity relationships of anticancer ruthenium(II) complexes with substituted hydroxyquinolines.

Authors:  Dmytro Havrylyuk; Brock S Howerton; Leona Nease; Sean Parkin; David K Heidary; Edith C Glazer
Journal:  Eur J Med Chem       Date:  2018-04-30       Impact factor: 6.514

Review 6.  Zebrafish assays for drug toxicity screening.

Authors:  Amy L Rubinstein
Journal:  Expert Opin Drug Metab Toxicol       Date:  2006-04       Impact factor: 4.481

7.  Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl-l-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols.

Authors:  Shusuke Ogihara; Toru Komatsu; Yukihiro Itoh; Yuka Miyake; Takayoshi Suzuki; Kouichi Yanagi; Yusuke Kimura; Tasuku Ueno; Kenjiro Hanaoka; Hirotatsu Kojima; Takayoshi Okabe; Tetsuo Nagano; Yasuteru Urano
Journal:  J Am Chem Soc       Date:  2019-12-23       Impact factor: 15.419

8.  Identification of drugs that restore primary cilium expression in cancer cells.

Authors:  Niamat Ali Khan; Nicolas Willemarck; Ali Talebi; Arnaud Marchand; Maria Mercedes Binda; Jonas Dehairs; Natalia Rueda-Rincon; Veerle W Daniels; Muralidhararao Bagadi; Deepak Balaji Thimiri Govinda Raj; Frank Vanderhoydonc; Sebastian Munck; Patrick Chaltin; Johannes V Swinnen
Journal:  Oncotarget       Date:  2016-03-01

9.  New Ru(ii) photocages operative with near-IR light: new platform for drug delivery in the PDT window.

Authors:  Malik H Al-Afyouni; Thomas N Rohrabaugh; Kathlyn F Al-Afyouni; Claudia Turro
Journal:  Chem Sci       Date:  2018-07-20       Impact factor: 9.825

10.  Modifying charge and hydrophilicity of simple Ru(II) polypyridyl complexes radically alters biological activities: old complexes, surprising new tricks.

Authors:  Matthew Dickerson; Yang Sun; Brock Howerton; Edith C Glazer
Journal:  Inorg Chem       Date:  2014-09-24       Impact factor: 5.165
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  2 in total

1.  Quantum mechanical study of interactions between sunscreen ingredients and nucleotide bases.

Authors:  Kyle R Volk; Leah B Casabianca
Journal:  J Mol Model       Date:  2022-08-04       Impact factor: 2.172

2.  Biological Investigations of Ru(II) Complexes With Diverse β-diketone Ligands.

Authors:  Raphael T Ryan; Dmytro Havrylyuk; Kimberly C Stevens; L Henry Moore; Sean Parkin; Jessica S Blackburn; David K Heidary; John P Selegue; Edith C Glazer
Journal:  Eur J Inorg Chem       Date:  2021-07-21       Impact factor: 2.551
  2 in total

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