Literature DB >> 3284472

Tissue stress and tumor promotion. Possible relevance to epidermolysis bullosa.

G I Goldberg1, A Z Eisen, E A Bauer.   

Abstract

Cutaneous carcinomas often arise in patients with severe epidermolysis bullosa (or other cutaneous ulcers) at multiple primary sites. Chronic tissue stress thus appears to promote carcinogenesis in preexisting somatic mutants in a stem cell population. Altered contractile properties of fibroblasts cultured from skin with epidermolysis bullosa may result from an altered interaction of these cells with their surrounding, chronically stressed, connective tissue matrix.

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Year:  1988        PMID： 3284472

Source DB:  PubMed          Journal:  Arch Dermatol        ISSN： 0003-987X


  7 in total

1.  Preliminary evaluation of cord blood platelet gel for the treatment of skin lesions in children with dystrophic epidermolysis bullosa.

Authors:  Gianluca Tadini; Sophie Guez; Lidia Pezzani; Maurizio Marconi; Noemi Greppi; Francesca Manzoni; Paolo Rebulla; Susanna Esposito
Journal:  Blood Transfus       Date:  2014-10-29       Impact factor: 3.443

2.  Basic fibroblast growth factor: a missing link between collagen VII, increased collagenase, and squamous cell carcinoma in recessive dystrophic epidermolysis bullosa.

Authors:  J L Arbiser; J D Fine; D Murrell; A Paller; S Connors; K Keough; E Marsh; J Folkman
Journal:  Mol Med       Date:  1998-03       Impact factor: 6.354

3.  [Parallels between wound healing, chronic inflammatory skin diseases and neoplasia: clinical aspects].

Authors:  A Brown; I Tantcheva-Poor; S A Eming
Journal:  Hautarzt       Date:  2014-11       Impact factor: 0.751

4.  Early invasive vulvar squamous cell carcinoma arising in a woman with vulvar pemphigus vulgaris and systemic lupus erythematosus.

Authors:  Giuseppe Bifulco; Vincenzo D Mandato; Roberto Piccoli; Pierluigi Giampaolino; Chiara Mignogna; Michele D Mignogna; Luigi Costagliola; Carmine Nappi
Journal:  BMC Cancer       Date:  2010-06-23       Impact factor: 4.430

5.  Patients with severe forms of inherited epidermolysis bullosa exhibit decreased lymphokine and monokine production.

Authors:  V Chopra; S K Tyring; L Johnson; J D Fine
Journal:  J Clin Immunol       Date:  1990-11       Impact factor: 8.317

6.  Down-regulation of laminin-5 in breast carcinoma cells.

Authors:  K J Martin; C P Kwan; K Nagasaki; X Zhang; M J O'Hare; C M Kaelin; R E Burgeson; A B Pardee; R Sager
Journal:  Mol Med       Date:  1998-09       Impact factor: 6.354

7.  Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen.

Authors:  Vera L Martins; Jashmin J Vyas; Mei Chen; Karin Purdie; Charles A Mein; Andrew P South; Alan Storey; John A McGrath; Edel A O'Toole
Journal:  J Cell Sci       Date:  2009-05-12       Impact factor: 5.285
  7 in total

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