Literature DB >> 3284459

Antibacterial activities of fluorovinyl- and chlorovinylglycine and several derived dipeptides.

A A Patchett1, D Taub, B Weissberger, M E Valiant, H Gadebusch, N A Thornberry, H G Bull.   

Abstract

The in vitro antibacterial activities of several halovinylglycine compounds and their L-norvalyl peptide derivatives are presented. The most potent of them, L-norvalyl-L-chlorovinylglycine, displayed good activity against gram-positive organisms, including methicillin-resistant Staphylococcus species. Chlorovinylglycine is an efficient inhibitor of alanine racemase, but the antibacterial activity of L-norvalyl-L-chlorovinylglycine may involve other physiological targets as well.

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Year:  1988        PMID： 3284459      PMCID： PMC172167          DOI： 10.1128/AAC.32.3.319

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Chloroalanyl antibiotic peptides: antagonism of their antimicrobial effects by L-alanine and L-alanyl peptides in gram-negative bacteria.

Authors:  K S Cheung; W Boisvert; S A Lerner; M Johnston
Journal:  J Med Chem       Date:  1986-10       Impact factor: 7.446

2.  Suicide substrates for the alanine racemase of Escherichia coli B.

Authors:  E Wang; C Walsh
Journal:  Biochemistry       Date:  1978-04-04       Impact factor: 3.162

3.  Phosphonopeptides as antibacterial agents: rationale, chemistry, and structure-activity relationships.

Authors:  F R Atherton; M J Hall; C H Hassall; R W Lambert; P S Ringrose
Journal:  Antimicrob Agents Chemother       Date:  1979-05       Impact factor: 5.191

4.  Phosphonopeptides, a new class of synthetic antibacterial agents.

Authors:  J G Allen; F R Atherton; M J Hall; C H Hassall; S W Holmes; R W Lambert; L J Nisbet; P S Ringrose
Journal:  Nature       Date:  1978-03-02       Impact factor: 49.962

Review 5.  Inhibition of cell wall biosynthesis by analogues and alanine.

Authors:  F C Neuhaus; W P Hammes
Journal:  Pharmacol Ther       Date:  1981       Impact factor: 12.310

6.  Letter: New antibacterial agent via photofluorination of a bacterial cell wall constituent.

Authors:  J Kollonitsch; L Barash; F M Kahan; H Kropp
Journal:  Nature       Date:  1973-06-08       Impact factor: 49.962

7.  Chloralanyl and propargylglycyl dipeptides. Suicide substrate containing antibacterials.

Authors:  K S Cheung; S A Wasserman; E Dudek; S A Lerner; M Johnston
Journal:  J Med Chem       Date:  1983-12       Impact factor: 7.446

8.  The structure of bacilysin and other products of Bacillus subtilis.

Authors:  J E Walker; E P Abraham
Journal:  Biochem J       Date:  1970-07       Impact factor: 3.857

9.  Phosphonopeptides as antibacterial agents: alaphosphin and related phosphonopeptides.

Authors:  J G Allen; F R Atherton; M J Hall; C H Hassall; S W Holmes; R W Lambert; L J Nisbet; P S Ringrose
Journal:  Antimicrob Agents Chemother       Date:  1979-05       Impact factor: 5.191

10.  Phosphonopeptide antibacterial agents related to alafosfalin: design, synthesis, and structure-activity relationships.

Authors:  F R Atherton; M J Hall; C H Hassall; S W Holmes; R W Lambert; W J Lloyd; P S Ringrose
Journal:  Antimicrob Agents Chemother       Date:  1980-12       Impact factor: 5.191
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  2 in total

1.  Synthesis of Higher α-Chlorovinyl and α-Bromovinyl Amino Acids: The Amino Protecting Group Determines the Reaction Course.

Authors:  David B Berkowitz; Michelle L Pedersen; Wan-Jin Jahng
Journal:  Tetrahedron Lett       Date:  1996-06-17       Impact factor: 2.415

Review 2.  Amino Acid Based Antimicrobial Agents - Synthesis and Properties.

Authors:  Michał G Nowak; Andrzej S Skwarecki; Maria J Milewska
Journal:  ChemMedChem       Date:  2021-10-01       Impact factor: 3.540
  2 in total

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