Literature DB >> 32840139

Structure of human ATG9A: how holey art thou?

Wayne D Hawkins1,2, Daniel J Klionsky1,2.   

Abstract

Several studies have provided insight into the unique intracellular localization, dynamic trafficking and diverse repertoire of binding partners of Atg9/ATG9, but structural details of the protein have remained elusive. Guardia and colleagues now report the structure of human ATG9A to a resolution of 2.9 Å, revealing, among other features, an elaborate system of tunnels permeating the ATG9A protein complex.

Entities:  

Keywords:  Autophagy; lipid transfer; lysosome; membrane protein; protein structure; stress

Year:  2020        PMID： 32840139      PMCID： PMC7595600          DOI： 10.1080/15548627.2020.1810901

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  10 in total

1.  Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy.

Authors:  Congcong He; Misuzu Baba; Yang Cao; Daniel J Klionsky
Journal:  Mol Biol Cell       Date:  2008-10-01       Impact factor: 4.138

2.  Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.

Authors:  Carlos M Guardia; Xiao-Feng Tan; Tengfei Lian; Mitra S Rana; Wenchang Zhou; Eric T Christenson; Augustus J Lowry; José D Faraldo-Gómez; Juan S Bonifacino; Jiansen Jiang; Anirban Banerjee
Journal:  Cell Rep       Date:  2020-06-30       Impact factor: 9.423

3.  Subnanometer resolution cryo-EM structure of Arabidopsis thaliana ATG9.

Authors:  Louis Tung Faat Lai; Chuanyang Yu; Jan Siu Kei Wong; Ho Sing Lo; Samir Benlekbir; Liwen Jiang; Wilson Chun Yu Lau
Journal:  Autophagy       Date:  2019-07-16       Impact factor: 16.016

4.  Atg2 mediates direct lipid transfer between membranes for autophagosome formation.

Authors:  Takuo Osawa; Tetsuya Kotani; Tatsuya Kawaoka; Eri Hirata; Kuninori Suzuki; Hitoshi Nakatogawa; Yoshinori Ohsumi; Nobuo N Noda
Journal:  Nat Struct Mol Biol       Date:  2019-03-25       Impact factor: 15.369

5.  Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae.

Authors:  Fulvio Reggiori; Chao-Wen Wang; Usha Nair; Takahiro Shintani; Hagai Abeliovich; Daniel J Klionsky
Journal:  Mol Biol Cell       Date:  2004-03-05       Impact factor: 4.138

6.  Atg9 vesicles are an important membrane source during early steps of autophagosome formation.

Authors:  Hayashi Yamamoto; Soichiro Kakuta; Tomonobu M Watanabe; Akira Kitamura; Takayuki Sekito; Chika Kondo-Kakuta; Rie Ichikawa; Masataka Kinjo; Yoshinori Ohsumi
Journal:  J Cell Biol       Date:  2012-07-23       Impact factor: 10.539

7.  An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis.

Authors:  Muriel Mari; Janice Griffith; Ester Rieter; Lakshmi Krishnappa; Daniel J Klionsky; Fulvio Reggiori
Journal:  J Cell Biol       Date:  2010-09-20       Impact factor: 10.539

8.  OPM database and PPM web server: resources for positioning of proteins in membranes.

Authors:  Mikhail A Lomize; Irina D Pogozheva; Hyeon Joo; Henry I Mosberg; Andrei L Lomize
Journal:  Nucleic Acids Res       Date:  2011-09-02       Impact factor: 16.971

9.  Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores.

Authors:  Rubén Gómez-Sánchez; Jaqueline Rose; Rodrigo Guimarães; Muriel Mari; Daniel Papinski; Ester Rieter; Willie J Geerts; Ralph Hardenberg; Claudine Kraft; Christian Ungermann; Fulvio Reggiori
Journal:  J Cell Biol       Date:  2018-05-30       Impact factor: 10.539

10.  Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum.

Authors:  Elizabeth L Axe; Simon A Walker; Maria Manifava; Priya Chandra; H Llewelyn Roderick; Anja Habermann; Gareth Griffiths; Nicholas T Ktistakis
Journal:  J Cell Biol       Date:  2008-08-25       Impact factor: 10.539
  10 in total

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