| Literature DB >> 32839608 |
Susanna S Ng1,2,3, Fabian De Labastida Rivera1, Juming Yan1,4, Dillon Corvino1,4,3, Indrajit Das1, Ping Zhang1, Rachel Kuns1, Shashi Bhushan Chauhan5, Jiajie Hou1, Xian-Yang Li1, Teija C M Frame1,4, Benjamin A McEnroe1, Eilish Moore1,4, Jinrui Na1,4, Jessica A Engel1, Megan S F Soon1,4, Bhawana Singh5, Andrew J Kueh6,7, Marco J Herold6,7, Marcela Montes de Oca1, Siddharth Sankar Singh5, Patrick T Bunn1,8, Amy Roman Aguilera1, Mika Casey1, Matthias Braun1, Nazanin Ghazanfari9, Shivangi Wani1,10, Yulin Wang1,2, Fiona H Amante1, Chelsea L Edwards1,4, Ashraful Haque1, William C Dougall1, Om Prakash Singh11, Alan G Baxter12, Michele W L Teng1, Alex Loukas13, Norelle L Daly13, Nicole Cloonan1,14, Mariapia A Degli-Esposti15,16, Jude Uzonna17, William R Heath9, Tobias Bald1, Siok-Keen Tey1, Kyohei Nakamura1, Geoffrey R Hill18, Rajiv Kumar5,19, Shyam Sundar5, Mark J Smyth1, Christian R Engwerda20.
Abstract
Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4+ and CD8+ T cells played key roles in promoting inflammation during visceral leishmaniasis and malaria-two important parasitic diseases. Additionally, NKG7 expressed by natural killer cells was critical for controlling cancer initiation, growth and metastasis. NKG7 function in natural killer and CD8+ T cells was linked with their ability to regulate the translocation of CD107a to the cell surface and kill cellular targets, while NKG7 also had a major impact on CD4+ T cell activation following infection. Thus, we report a novel therapeutic target expressed on a range of immune cells with functions in different immune responses.Entities:
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Year: 2020 PMID： 32839608 PMCID： PMC7965849 DOI： 10.1038/s41590-020-0758-6
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606