| Literature DB >> 32837871 |
Tingxu Jin1, Jun Li1, Jun Yang2, Jiawei Li2, Feng Hong1, Hai Long3, Qihong Deng4, Yong Qin1, Jiajun Jiang2, Xuan Zhou5, Qian Song2, Chunliu Pan2, Peng Luo1.
Abstract
As coronavirus disease 2019 (COVID-19) is spreading worldwide, there have been arguments regarding the aerosol transmission of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, some re-detectable positive (RP) patients have been reported. However, little attention has been given to the follow-up of recovered patients, and there is no environmental evidence to determine whether these patients continue to shed the virus after they test negative. Therefore, with an objective to test the hypothesis of airborne transmission of SARS-CoV-2, it is necessary to 1) determine whether SARS-CoV-2 particles are present in the indoor air and 2) determine whether recovered patients are still shedding virus, thus providing much-needed environmental evidence for the management of COVID-19 patients during the recovery period. In this study, surface and air samples were collected from an intensive care unit (ICU) containing one ready-for-discharge patient. All surface samples tested negative, but the air samples tested positive for SARS-CoV-2. This implies that SARS-CoV-2 particles may be shed in aerosol form for days after patients test negative. This finding may be one of the reasons for the observation of RP patients; therefore, there is a need for improved clinical and disease management guidelines for recovered COVID-19 patients.Entities:
Keywords: AURI, Acute upper respiratory infection; Aerosol; COVID-19, Coronavirus disease; Ct, Cycle threshold; ICU; Indoor Air Environment; MERS-CoV, Middle East respiratory syndrome coronavirus; NP, Nucleocapsid protein; ORF1ab, Open reading frame; QRT-PCR, Quantitative real-time polymerase chain reaction; RP, Re-detectable positive patients; Re-detectable Positive; Ready-for-discharge Patient; SARS-CoV-2; SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
Year: 2020 PMID: 32837871 PMCID: PMC7428766 DOI: 10.1016/j.scs.2020.102446
Source DB: PubMed Journal: Sustain Cities Soc ISSN: 2210-6707 Impact factor: 7.587