Literature DB >> 32837871

SARS-CoV-2 presented in the air of an intensive care unit (ICU).

Tingxu Jin1, Jun Li1, Jun Yang2, Jiawei Li2, Feng Hong1, Hai Long3, Qihong Deng4, Yong Qin1, Jiajun Jiang2, Xuan Zhou5, Qian Song2, Chunliu Pan2, Peng Luo1.   

Abstract

As coronavirus disease 2019 (COVID-19) is spreading worldwide, there have been arguments regarding the aerosol transmission of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, some re-detectable positive (RP) patients have been reported. However, little attention has been given to the follow-up of recovered patients, and there is no environmental evidence to determine whether these patients continue to shed the virus after they test negative. Therefore, with an objective to test the hypothesis of airborne transmission of SARS-CoV-2, it is necessary to 1) determine whether SARS-CoV-2 particles are present in the indoor air and 2) determine whether recovered patients are still shedding virus, thus providing much-needed environmental evidence for the management of COVID-19 patients during the recovery period. In this study, surface and air samples were collected from an intensive care unit (ICU) containing one ready-for-discharge patient. All surface samples tested negative, but the air samples tested positive for SARS-CoV-2. This implies that SARS-CoV-2 particles may be shed in aerosol form for days after patients test negative. This finding may be one of the reasons for the observation of RP patients; therefore, there is a need for improved clinical and disease management guidelines for recovered COVID-19 patients.
© 2020 Published by Elsevier Ltd.

Entities:  

Keywords:  AURI, Acute upper respiratory infection; Aerosol; COVID-19, Coronavirus disease; Ct, Cycle threshold; ICU; Indoor Air Environment; MERS-CoV, Middle East respiratory syndrome coronavirus; NP, Nucleocapsid protein; ORF1ab, Open reading frame; QRT-PCR, Quantitative real-time polymerase chain reaction; RP, Re-detectable positive patients; Re-detectable Positive; Ready-for-discharge Patient; SARS-CoV-2; SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2

Year:  2020        PMID: 32837871      PMCID: PMC7428766          DOI: 10.1016/j.scs.2020.102446

Source DB:  PubMed          Journal:  Sustain Cities Soc        ISSN: 2210-6707            Impact factor:   7.587


  6 in total

1.  Evaporation and dispersion of respiratory droplets from coughing.

Authors:  L Liu; J Wei; Y Li; A Ooi
Journal:  Indoor Air       Date:  2016-03-23       Impact factor: 5.770

2.  Evidence of airborne transmission of the severe acute respiratory syndrome virus.

Authors:  Ignatius T S Yu; Yuguo Li; Tze Wai Wong; Wilson Tam; Andy T Chan; Joseph H W Lee; Dennis Y C Leung; Tommy Ho
Journal:  N Engl J Med       Date:  2004-04-22       Impact factor: 91.245

3.  Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient.

Authors:  Xiao-Hong Yao; Zhi-Cheng He; Ting-Yuan Li; Hua-Rong Zhang; Yan Wang; Huaming Mou; Qiaonan Guo; Shi-Cang Yu; Yanqing Ding; Xindong Liu; Yi-Fang Ping; Xiu-Wu Bian
Journal:  Cell Res       Date:  2020-04-28       Impact factor: 25.617

4.  Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong.

Authors:  Vincent C C Cheng; Shuk-Ching Wong; Jonathan H K Chen; Cyril C Y Yip; Vivien W M Chuang; Owen T Y Tsang; Siddharth Sridhar; Jasper F W Chan; Pak-Leung Ho; Kwok-Yung Yuen
Journal:  Infect Control Hosp Epidemiol       Date:  2020-03-05       Impact factor: 3.254

5.  Efficacy of a carrageenan nasal spray in patients with common cold: a randomized controlled trial.

Authors:  Martin Ludwig; Elisabeth Enzenhofer; Sven Schneider; Margit Rauch; Angelika Bodenteich; Kurt Neumann; Eva Prieschl-Grassauer; Andreas Grassauer; Thomas Lion; Christian A Mueller
Journal:  Respir Res       Date:  2013-11-13

6.  Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.

Authors:  Neeltje van Doremalen; Trenton Bushmaker; Dylan H Morris; Myndi G Holbrook; Amandine Gamble; Brandi N Williamson; Azaibi Tamin; Jennifer L Harcourt; Natalie J Thornburg; Susan I Gerber; James O Lloyd-Smith; Emmie de Wit; Vincent J Munster
Journal:  N Engl J Med       Date:  2020-03-17       Impact factor: 91.245

  6 in total
  18 in total

1.  Clinical characteristics and prediction analysis of the recovered COVID-19 patients with re-detectable positive RNA test.

Authors:  Qi Li; Li Shuai; Li Tan; Lijun Song; Chongyang Ou; Xiaocheng Song; Jian He; Ming Gao; Xinyu Hu; Yang Liu; Hui Chen; Zui Zou; Chao Yu; Baodong Qin; Wenyun Xu
Journal:  Am J Transl Res       Date:  2021-12-15       Impact factor: 4.060

Review 2.  COVID-19 false dichotomies and a comprehensive review of the evidence regarding public health, COVID-19 symptomatology, SARS-CoV-2 transmission, mask wearing, and reinfection.

Authors:  Kevin Escandón; Angela L Rasmussen; Isaac I Bogoch; Eleanor J Murray; Karina Escandón; Saskia V Popescu; Jason Kindrachuk
Journal:  BMC Infect Dis       Date:  2021-07-27       Impact factor: 3.090

3.  Investigation of SARS-CoV-2 in hospital indoor air of COVID-19 patients' ward with impinger method.

Authors:  Mehdi Vosoughi; Chiman Karami; Abdollah Dargahi; Farhad Jeddi; Kamyar Mazloum Jalali; Aidin Hadisi; Somayeh Biparva Haghighi; Hadi Peeri Dogahe; Zahra Noorimotlagh; Seyyed Abbas Mirzaee
Journal:  Environ Sci Pollut Res Int       Date:  2021-05-06       Impact factor: 4.223

4.  COVID-19 and urban spaces: A new integrated CFD approach for public health opportunities.

Authors:  Asmaa M Hassan; Naglaa A Megahed
Journal:  Build Environ       Date:  2021-07-12       Impact factor: 6.456

5.  Characteristics and evaluation of the effectiveness of monitoring and control measures for the first 69 Patients with COVID-19 from 18 January 2020 to 2 March in Wuxi, China.

Authors:  Ping Shi; Yumeng Gao; Yuan Shen; Enping Chen; Hai Chen; Juan Liu; Yujun Chen; Yong Xiao; KeWei Wang; Chao Shi; Bing Lu
Journal:  Sustain Cities Soc       Date:  2020-10-17       Impact factor: 10.696

Review 6.  SARS-CoV-2: a systematic review of indoor air sampling for virus detection.

Authors:  João Tito Borges; Liane Yuri Kondo Nakada; Milena Guedes Maniero; José Roberto Guimarães
Journal:  Environ Sci Pollut Res Int       Date:  2021-02-25       Impact factor: 5.190

7.  Exploring spatiotemporal effects of the driving factors on COVID-19 incidences in the contiguous United States.

Authors:  Arabinda Maiti; Qi Zhang; Srikanta Sannigrahi; Suvamoy Pramanik; Suman Chakraborti; Artemi Cerda; Francesco Pilla
Journal:  Sustain Cities Soc       Date:  2021-02-19       Impact factor: 7.587

8.  Assessment of Air Contamination by SARS-CoV-2 in Hospital Settings.

Authors:  Gabriel Birgand; Nathan Peiffer-Smadja; Sandra Fournier; Solen Kerneis; François-Xavier Lescure; Jean-Christophe Lucet
Journal:  JAMA Netw Open       Date:  2020-12-01

9.  A systematic review and meta-analysis of discharged COVID-19 patients retesting positive for RT-PCR.

Authors:  Xiangying Ren; Xiangge Ren; Jiaao Lou; Yongbo Wang; Qiao Huang; Yuexian Shi; Yuqing Deng; Xiaoyan Li; Liye Lu; Siyu Yan; Yunyun Wang; Lisha Luo; Xiantao Zeng; Xiaomei Yao; Yinghui Jin
Journal:  EClinicalMedicine       Date:  2021-04-17

10.  Indoor air quality improvement in COVID-19 pandemic: Review.

Authors:  Nehul Agarwal; Chandan Swaroop Meena; Binju P Raj; Lohit Saini; Ashok Kumar; N Gopalakrishnan; Anuj Kumar; Nagesh Babu Balam; Tabish Alam; Nishant Raj Kapoor; Vivek Aggarwal
Journal:  Sustain Cities Soc       Date:  2021-04-15       Impact factor: 7.587

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