Literature DB >> 32829025

The antiviral activities of TRIM proteins.

Lennart Koepke1, Michaela U Gack2, Konstantin Mj Sparrer3.   

Abstract

Tripartite motif (TRIM) proteins are a highly versatile family of host-cell factors that play an integral role in the mammalian defense against pathogens. TRIM proteins regulate either transcription-dependent antiviral responses such as pro-inflammatory cytokine induction, or they modulate other important cell-intrinsic defense pathways like autophagy. Additionally, TRIM proteins exert direct antiviral activity whereby they antagonize specific viral components through diverse mechanisms. Here, we summarize the latest discoveries on the molecular mechanisms of antiviral TRIM proteins and also discuss current and future trends in this fast-evolving field.
Copyright © 2020 Elsevier Ltd. All rights reserved.

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Year:  2020        PMID： 32829025      PMCID： PMC7440025          DOI： 10.1016/j.mib.2020.07.005

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  15 in total

1.  Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.

Authors:  Tanaya Bagga; Nikhil Kumar Tulsian; Yu Keung Mok; R Manjunatha Kini; J Sivaraman
Journal:  Cell Mol Life Sci       Date:  2022-04-10       Impact factor: 9.261

2.  A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.

Authors:  Xiao Liang; Jun Xiao; Xuzichao Li; Yujie Liu; Yao Lu; Yanan Wen; Zexing Li; Xing Che; Yongjian Ma; Xingyan Zhang; Yi Zhang; Deng Jian; Peihui Wang; Chenghao Xuan; Guimei Yu; Long Li; Heng Zhang
Journal:  Nat Chem Biol       Date:  2022-08-18       Impact factor: 16.174

Review 3.  The role of PI3K/AKT signaling pathway in gallbladder carcinoma.

Authors:  Zeyu Wu; Xiao Yu; Shuijun Zhang; Yuting He; Wenzhi Guo
Journal:  Am J Transl Res       Date:  2022-07-15       Impact factor: 3.940

4.  MicroRNA-376b-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Restriction Factor TRIM22.

Authors:  Jing Chen; Shijie Zhao; Zhiying Cui; Wen Li; Pengli Xu; Huimin Liu; Xinyong Miao; Yu Chen; Fangfang Han; Hongying Zhang; Pingan Xia; Yina Zhang
Journal:  J Virol       Date:  2021-11-10       Impact factor: 6.549

5.  Knockdown of TRIM5α or TRIM11 increases lentiviral vector transduction efficiency of human Muller cells.

Authors:  Monica M Sauter; Curtis R Brandt
Journal:  Exp Eye Res       Date:  2021-01-10       Impact factor: 3.467

Review 6.  Evolutionary conflicts and adverse effects of antiviral factors.

Authors:  Daniel Sauter; Frank Kirchhoff
Journal:  Elife       Date:  2021-01-15       Impact factor: 8.140

Review 7.  The Function of the PRRSV-Host Interactions and Their Effects on Viral Replication and Propagation in Antiviral Strategies.

Authors:  Jun Ma; Lulu Ma; Meiting Yang; Wei Wu; Wenhai Feng; Zhongzhou Chen
Journal:  Vaccines (Basel)       Date:  2021-04-09

Review 8.  Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion.

Authors:  Xiu-Zhong Zhang; Fu-Huang Li; Xiao-Jia Wang
Journal:  Front Microbiol       Date:  2021-12-01       Impact factor: 5.640

9.  Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection.

Authors:  Matthew Charman; Steven McFarlane; Joanna K Wojtus; Elizabeth Sloan; Rebecca Dewar; Gail Leeming; Mohammed Al-Saadi; Laura Hunter; Miles W Carroll; James P Stewart; Paul Digard; Edward Hutchinson; Chris Boutell
Journal:  Front Cell Infect Microbiol       Date:  2021-09-21       Impact factor: 5.293

10.  A Promising Intracellular Protein-Degradation Strategy: TRIMbody-Away Technique Based on Nanobody Fragment.

Authors:  Gang Chen; Yu Kong; You Li; Ailing Huang; Chunyu Wang; Shanshan Zhou; Zhenlin Yang; Yanling Wu; Jianke Ren; Tianlei Ying
Journal:  Biomolecules       Date:  2021-10-14
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