Yingyue Huang1, Chaoqiang Jiang2, Lin Xu3, Weisen Zhang4, Feng Zhu2, Yali Jin2, Kar Keung Cheng5, Tai Hing Lam6. 1. School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. 2. Molecular Epidemiology Research Centre, Guangzhou No.12 Hospital, Guangzhou 510620, China. 3. School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; School of Public Health, the University of Hong Kong, Hong Kong 999077, China. Electronic address: xulin27@mail.sysu.edu.cn. 4. Molecular Epidemiology Research Centre, Guangzhou No.12 Hospital, Guangzhou 510620, China. Electronic address: zwsgzcn@163.com. 5. Institute of Applied Health Research, University of Birmingham, Birmingham B15 2TT, UK. 6. Molecular Epidemiology Research Centre, Guangzhou No.12 Hospital, Guangzhou 510620, China; School of Public Health, the University of Hong Kong, Hong Kong 999077, China.
Abstract
BACKGROUND: Physical activity (PA) is generally encouraged. Studies from developed countries in the West have shown that maintenance of adequate PA or increasing PA are associated with lower mortality risk. It is unclear whether these associations apply to an older Chinese population. Hence, we examined the changes in PA prospectively among a middle-aged and older Chinese population over an average of 4 years and explored their subsequent mortality risks. METHODS: Metabolic equivalent scores of PA among participants in the Guangzhou Biobank Cohort Study were calculated. Participants were divided into 3 groups related to PA level, and changes in PA were classified into 9 categories. Information on vital status and causes of death from March 2008 to December 2012 (the first repeated examination) until December 31, 2017, was obtained via record linkage with the Death Registry. RESULTS: Of 18,104 participants aged 61.21 ± 6.85 years (mean ± SD), 1461 deaths occurred within 141,417 person-years. Compared to participants who maintained moderate PA, those who decreased PA from moderate or high levels to a low level had increased risks for all-cause mortality (hazard ratio (HR) = 1.47, 95% confidence interval (95%CI): 1.11-1.96). Participants who maintained a high level of PA (HR = 0.83, 95%CI: 0.70-0.98) or increased PA from low to high levels (HR = 0.71, 95%CI: 0.52-0.97) showed lower all-cause mortality risks. Those who maintained low PA levels showed a higher all-cause mortality risk, whereas those who increased their PA levels showed a non-significantly lower risk. Similar results were found for cardiovascular disease risk. CONCLUSION: Even at an older age, maintaining a high PA level or increasing PA from low to high levels results in lower mortality risks, suggesting that substantial health benefits might be achieved by maintaining or increasing engagement in adequate levels of PA. The increased risk of maintaining a low PA level or decreasing PA to a low level warrants the attention of public health officials and clinicians.
BACKGROUND: Physical activity (PA) is generally encouraged. Studies from developed countries in the West have shown that maintenance of adequate PA or increasing PA are associated with lower mortality risk. It is unclear whether these associations apply to an older Chinese population. Hence, we examined the changes in PA prospectively among a middle-aged and older Chinese population over an average of 4 years and explored their subsequent mortality risks. METHODS: Metabolic equivalent scores of PA among participants in the Guangzhou Biobank Cohort Study were calculated. Participants were divided into 3 groups related to PA level, and changes in PA were classified into 9 categories. Information on vital status and causes of death from March 2008 to December 2012 (the first repeated examination) until December 31, 2017, was obtained via record linkage with the Death Registry. RESULTS: Of 18,104 participants aged 61.21 ± 6.85 years (mean ± SD), 1461 deaths occurred within 141,417 person-years. Compared to participants who maintained moderate PA, those who decreased PA from moderate or high levels to a low level had increased risks for all-cause mortality (hazard ratio (HR) = 1.47, 95% confidence interval (95%CI): 1.11-1.96). Participants who maintained a high level of PA (HR = 0.83, 95%CI: 0.70-0.98) or increased PA from low to high levels (HR = 0.71, 95%CI: 0.52-0.97) showed lower all-cause mortality risks. Those who maintained low PA levels showed a higher all-cause mortality risk, whereas those who increased their PA levels showed a non-significantly lower risk. Similar results were found for cardiovascular disease risk. CONCLUSION: Even at an older age, maintaining a high PA level or increasing PA from low to high levels results in lower mortality risks, suggesting that substantial health benefits might be achieved by maintaining or increasing engagement in adequate levels of PA. The increased risk of maintaining a low PA level or decreasing PA to a low level warrants the attention of public health officials and clinicians.
Authors: Jiao Wang; Wei Sen Zhang; Chao Qiang Jiang; Feng Zhu; Ya Li Jin; Kar Keung Cheng; Tai Hing Lam; Lin Xu Journal: BMC Med Date: 2022-05-02 Impact factor: 11.150
Authors: Wen Bo Tian; Wei Sen Zhang; Chao Qiang Jiang; Xiang Yi Liu; Ya Li Jin; Tai Hing Lam; Kar Keung Cheng; Lin Xu Journal: Lancet Reg Health West Pac Date: 2022-05-03