| Literature DB >> 32827663 |
Xixi Tian1, Shengzheng Zhang2, Qiong Zhang1, Licheng Kang2, Changzhen Ma2, Lifeng Feng2, Shengyu Li1, Jing Li2, Liang Yang2, Jie Liu2, Zhi Qi3, Yanna Shen4.
Abstract
Renal cell carcinoma (RCC) is one of the most common urologic malignant tumors. Current chemotherapy is not effective in RCC and results in some side effects. Resveratrol (RSV) has been reported to exert antitumor effects in some cancer cells; however the mechanism is not fully understood. Herein, we aimed to determine the anticancer effect of RSV on RCC and further explore the underlying molecular mechanism in this process. We found that RSV inhibited tumor cells proliferation, migration and invasion and increased apoptosis of RCC either in vivo or in vitro. RSV significantly down-regulated expressions of NLRP3 and its downstream genes. Inhibition of NLRP3 by NLRP3 small interfering RNA mimicked the effects of RSV on RCC cells. These results suggested that RSV could exert antitumor effect by depressing activity of NLRP3, and NLRP3 would be a promising clinical therapeutic strategy for RCC.Entities:
Keywords: Apoptosis; IL-1β; NLRP3; Renal cell carcinoma; Resveratrol
Mesh：
Substances：
Year: 2020 PMID： 32827663 DOI： 10.1016/j.jnutbio.2020.108489
Source DB: PubMed Journal: J Nutr Biochem ISSN： 0955-2863 Impact factor: 6.048