Osmoregulatory actions of prolactin in the gastrointestinal tract of fishes.

In fishes, prolactin (Prl) signaling underlies the homeostatic regulation of hydromineral balance by controlling essential solute and water transporting functions performed by the gill, gastrointestinal tract, kidney, urinary bladder, and integument. Comparative studies spanning over 60 years have firmly established that Prl promotes physiological activities that enable euryhaline and stenohaline teleosts to reside in freshwater environments; nonetheless, the specific molecular and cellular targets of Prl in ion- and water-transporting tissues are still being resolved. In this short review, we discuss how particular targets of Prl (e.g., ion cotransporters, tight-junction proteins, and ion pumps) confer adaptive functions to the esophagus and intestine. Additionally, in some instances, Prl promotes histological and functional transformations within esophageal and intestinal epithelia by regulating cell proliferation. Collectively, the demonstrated actions of Prl in the gastrointestinal tract of teleosts indicate that Prl operates to promote phenotypes supportive of freshwater acclimation and to inhibit phenotypes associated with seawater acclimation. We conclude our review by underscoring that future investigations are warranted to determine how growth hormone/Prl-family signaling evolved in basal fishes to support the gastrointestinal processes underlying hydromineral balance.