Literature DB >> 328268

Stimulation of glucagon release by addition of anti-stomatostatin serum to islets of Langerhans in vitro.

N Barden, M Lavoie, A Dupont, J Côté, J P Côté.   

Abstract

Addition of anti-somatostatin serum to rat islets of Langerhans which had been previously maintained in organ culture for 48h, resulted in a marked stimulation of glucagon release with no change in the rate of insulin secretion during the entire 90 min period during which the secretion of both hormones was followed. Prior saturation of the anti-somatostatin serum with somatostatin prevented the stimulatory acting on glucagon release. These data strongly suggest a physiological role for endogenous somatostatin in the control of glucagon secretion.

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Year:  1977        PMID： 328268     DOI： 10.1210/endo-101-2-635

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  8 in total

Review 1.  Glucagon-like peptide 1 (GLP-1).

Authors:  T D Müller; B Finan; S R Bloom; D D'Alessio; D J Drucker; P R Flatt; A Fritsche; F Gribble; H J Grill; J F Habener; J J Holst; W Langhans; J J Meier; M A Nauck; D Perez-Tilve; A Pocai; F Reimann; D A Sandoval; T W Schwartz; R J Seeley; K Stemmer; M Tang-Christensen; S C Woods; R D DiMarchi; M H Tschöp
Journal:  Mol Metab       Date:  2019-09-30       Impact factor: 7.422

2.  Determination of immunoreactive somatostatin in rat plasma and responses to arginine, glucose and glucagon infusion.

Authors:  M Utsumi; H Makimura; K Ishihara; S Morita; S Baba
Journal:  Diabetologia       Date:  1979-11       Impact factor: 10.122

3.  Effect of glucose/sulfonylurea interaction on release of insulin, glucagon, and somatostatin from isolated perfused rat pancreas.

Authors:  S Efendić; F Enzmann; A Nylén; K Uvnäs-Wallensten; R Luft
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

Review 4.  Paracrine interactions within islets of Langerhans.

Authors:  Duk-Su Koh; Jung-Hwa Cho; Liangyi Chen
Journal:  J Mol Neurosci       Date:  2012-04-13       Impact factor: 3.444

5.  Release of somatostatin-like immunoreactivity from incubated rat hypothalamus and cerebral cortex. Effects of glucose and glucoregulatory hormones.

Authors:  M Berelowitz; D Dudlak; L A Frohman
Journal:  J Clin Invest       Date:  1982-06       Impact factor: 14.808

6.  Somatostatin-like immunoreactivity in rat blood. Characterization, regional differences, and responses to oral and intravenous glucose.

Authors:  M Berelowitz; S Kronheim; B Pimstone; B Shapiro
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808

7.  Somatostatin: an endogenous peptide in the toad urinary bladder inhibits vasopressin-stimulated water flow.

Authors:  J N Forrest; S Reichlin; D B Goodman
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

8.  Regulating glucagon secretion: somatostatin in the spotlight.

Authors:  Guy A Rutter
Journal:  Diabetes       Date:  2009-02       Impact factor: 9.461
  8 in total

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