Literature DB >> 3282543

All three human ras genes are expressed in a wide range of tissues.

G Fiorucci1, A Hall.   

Abstract

We examined the expression of the ras gene family (Ha-ras, Ki-ras, N-ras) in human fetal tissues (14 week) and in several human tumor cell lines. Dot blot hybridization showed that the three ras genes were expressed in all of the samples analysed, with a range of expression between 10 and 180 molecules/cell. There was no correlation between levels of expression of ras genes and the type of ras gene activated in different tumor types.

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Year:  1988        PMID: 3282543     DOI: 10.1016/0167-4781(88)90076-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  9 in total

1.  Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.

Authors:  Rodney B Luwor; Yang Lu; Xinqun Li; Ke Liang; Zhen Fan
Journal:  Cancer Lett       Date:  2011-03-15       Impact factor: 8.679

2.  Detection of a rare point mutation in Ki-ras of a human bladder cancer xenograft by polymerase chain reaction and direct sequencing.

Authors:  S M Grimmond; D Raghavan; P J Russell
Journal:  Urol Res       Date:  1992

Review 3.  RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.

Authors:  Bingliang Fang
Journal:  Acta Biochim Biophys Sin (Shanghai)       Date:  2015-09-07       Impact factor: 3.848

4.  Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones.

Authors:  Mohammad Behforouz; Wen Cai; Farahnaz Mohammadi; Mark G Stocksdale; Zhengxiang Gu; Mohammad Ahmadian; Darric E Baty; Michele R Etling; Charmaine H Al-Anzi; Tyson M Swiftney; Lee R Tanzer; Ronald L Merriman; Nancy C Behforouz
Journal:  Bioorg Med Chem       Date:  2006-10-10       Impact factor: 3.641

5.  Functional specificity of ras isoforms: so similar but so different.

Authors:  Esther Castellano; Eugenio Santos
Journal:  Genes Cancer       Date:  2011-03

6.  Codon usage regulates human KRAS expression at both transcriptional and translational levels.

Authors:  Jingjing Fu; Yunkun Dang; Christopher Counter; Yi Liu
Journal:  J Biol Chem       Date:  2018-10-01       Impact factor: 5.157

Review 7.  Ras oncogenes: split personalities.

Authors:  Antoine E Karnoub; Robert A Weinberg
Journal:  Nat Rev Mol Cell Biol       Date:  2008-07       Impact factor: 94.444

8.  Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications.

Authors:  Sami S Azrak; Alicia Ginel-Picardo; Matthias Drosten; Mariano Barbacid; Eugenio Santos
Journal:  BMC Genomics       Date:  2013-10-25       Impact factor: 3.969

9.  Comparison of liver oncogenic potential among human RAS isoforms.

Authors:  Sook In Chung; Hyuk Moon; Hye-Lim Ju; Dae Yeong Kim; Kyung Joo Cho; Silvia Ribback; Frank Dombrowski; Diego F Calvisi; Simon Weonsang Ro
Journal:  Oncotarget       Date:  2016-02-09
  9 in total

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