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Literature DB >> 3282305

Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators.

G Romero¹, L Luttrell, A Rogol, K Zeller, E Hewlett, J Larner.

Abstract

BC3H1 myocytes release membrane-bound alkaline phosphatase to the incubation medium upon stimulation with insulin, following a time course that is consistent with the generation of dimyristoylglycerol and the appearance of a putative insulin mediator in the extracellular medium. The use of specific blocking agents shows, however, that alkaline phosphatase release and dimyristoylglycerol production are independent processes and that the blockade of either event inhibits the production of insulin mediator. These experiments suggest a new model of insulin action.

Entities: Chemical Gene

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Year: 1988 PMID： 3282305 DOI： 10.1126/science.3282305

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

33 in total

1. Glycosylphosphatidylinositol (GPI) hydrolysis by transforming growth factor-beta1 (TGF-beta1) as a potential early step in the inhibition of epithelial cell proliferation.

Authors: P Bogdanowicz; J P Pujol
Journal: Mol Cell Biochem Date: 2000-05 Impact factor: 3.396

Review 2. Intracellular traffic of newly synthesized proteins. Current understanding and future prospects.

Authors: V R Lingappa
Journal: J Clin Invest Date: 1989-03 Impact factor: 14.808

3. Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.

Authors: N R F Nascimento; L M A Lessa; M R Kerntopf; C M Sousa; R S Alves; M G R Queiroz; J Price; D B Heimark; J Larner; X Du; M Brownlee; A Gow; C Davis; M C Fonteles
Journal: Proc Natl Acad Sci U S A Date: 2005-12-22 Impact factor: 11.205

4. Recombinant human endothelin-converting enzyme ECE-1b is located in an intracellular compartment when expressed in polarized Madin-Darby canine kidney cells.

Authors: A Azarani; G Boileau; P Crine
Journal: Biochem J Date: 1998-07-15 Impact factor: 3.857

10. The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation.

Authors: Orla Hanrahan; Helena Webb; Robert O'Byrne; Elaine Brabazon; Achim Treumann; Jack D Sunter; Mark Carrington; H Paul Voorheis
Journal: PLoS Pathog Date: 2009-06-05 Impact factor: 6.823

Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators.

1. Glycosylphosphatidylinositol (GPI) hydrolysis by transforming growth factor-beta1 (TGF-beta1) as a potential early step in the inhibition of epithelial cell proliferation.

Review 2. Intracellular traffic of newly synthesized proteins. Current understanding and future prospects.

3. Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.

4. Recombinant human endothelin-converting enzyme ECE-1b is located in an intracellular compartment when expressed in polarized Madin-Darby canine kidney cells.

5. Anti-inositolglycan antibodies selectively block some of the actions of insulin in intact BC3H1 cells.

Review 6. Emerging functional roles for the glycosyl-phosphatidylinositol membrane protein anchor.

Review 7. The insulin receptor and the molecular mechanism of insulin action.

Review 8. The role of glycosyl-phosphoinositides in hormone action.

9. Effect of a phospho-oligosaccharidic putative insulin messenger on insulin release in rats.

10. The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation.