Literature DB >> 3282178

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides.

R J Deshaies1, B D Koch, M Werner-Washburne, E A Craig, R Schekman.   

Abstract

Depletion of a subset of 70K stress proteins in yeast mutants shows that they are involved in the post-translational import of precursor polypeptides into both mitochondria and the lumen of the endoplasmic reticulum. The identification of such a basic function may explain the remarkable evolutionary conservation of the gene family encoding these proteins.

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Year:  1988        PMID： 3282178     DOI： 10.1038/332800a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  427 in total

1.  Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria.

Authors:  U Fünfschilling; S Rospert
Journal:  Mol Biol Cell       Date:  1999-10       Impact factor: 4.138

2.  14-3-3 proteins form a guidance complex with chloroplast precursor proteins in plants.

Authors:  T May; J Soll
Journal:  Plant Cell       Date:  2000-01       Impact factor: 11.277

3.  The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation.

Authors:  J H Lim; F Martin; B Guiard; N Pfanner; W Voos
Journal:  EMBO J       Date:  2001-03-01       Impact factor: 11.598

4.  Targeting and insertion of C-terminally anchored proteins to the mitochondrial outer membrane is specific and saturable but does not strictly require ATP or molecular chaperones.

Authors:  L Lan; S Isenmann; B W Wattenberg
Journal:  Biochem J       Date:  2000-07-15       Impact factor: 3.857

5.  Divergent functional properties of the ribosome-associated molecular chaperone Ssb compared with other Hsp70s.

Authors:  C Pfund; P Huang; N Lopez-Hoyo; E A Craig
Journal:  Mol Biol Cell       Date:  2001-12       Impact factor: 4.138

Review 6.  Signals and receptors--the translocation machinery on the mitochondrial surface.

Authors:  E Schleiff
Journal:  J Bioenerg Biomembr       Date:  2000-02       Impact factor: 2.945

7.  Involvement of a chloroplast HSP70 heat shock protein in the integration of a protein (light-harvesting complex protein precursor) into the thylakoid membrane.

Authors:  S Yalovsky; H Paulsen; D Michaeli; P R Chitnis; R Nechushtai
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

8.  Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.

Authors:  R J Deshaies; R Schekman
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

9.  Translocation of proteins across the mitochondrial inner membrane, but not into the outer membrane, requires nucleoside triphosphates in the matrix.

Authors:  S T Hwang; G Schatz
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

10.  Synthesis of stress proteins is increased in individuals with homozygous PiZZ alpha 1-antitrypsin deficiency and liver disease.

Authors:  D H Perlmutter; M J Schlesinger; J A Pierce; P I Punsal; A L Schwartz
Journal:  J Clin Invest       Date:  1989-11       Impact factor: 14.808
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