| Literature DB >> 3282126 |
T Seene1, M Umnova, K Alev, A Pehme.
Abstract
Skeletal muscles which have a high oxidative potential are less sensitive to the catabolic action of dexamethasone. In fast-twitch white muscles, where the oxidative capacity is low, the alkaline proteinase activity as well as the rise in the number of lysosomes was more pronounced. It seems that the glucocorticoid-caused myopathy is a result of elevated degradation of contractile proteins. This process of degradation of contractile proteins begins in the myosine filaments and then spreads to the thin filaments and the z-line.Entities:
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Year: 1988 PMID： 3282126 DOI： 10.1016/0022-4731(88)90032-5
Source DB: PubMed Journal: J Steroid Biochem ISSN： 0022-4731 Impact factor: 4.292