Literature DB >> 32820778

Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC.

Qian Xie1, Mareike M Wiedmann2, Aishan Zhao1, Ivelisse R Pagan3, Richard P Novick3, Hiroaki Suga2, Tom W Muir1.   

Abstract

We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.

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Year:  2020        PMID： 32820778      PMCID： PMC7530097          DOI： 10.1039/d0cc04873a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  26 in total

1.  Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus.

Authors:  Gholson J Lyon; Jesse S Wright; Tom W Muir; Richard P Novick
Journal:  Biochemistry       Date:  2002-08-06       Impact factor: 3.162

Review 2.  Ribosomal production and in vitro selection of natural product-like peptidomimetics: the FIT and RaPID systems.

Authors:  Christopher J Hipolito; Hiroaki Suga
Journal:  Curr Opin Chem Biol       Date:  2012-03-06       Impact factor: 8.822

3.  Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions.

Authors:  Boyuan Wang; Aishan Zhao; Richard P Novick; Tom W Muir
Journal:  Mol Cell       Date:  2014-03-20       Impact factor: 17.970

Review 4.  Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance.

Authors:  Seth W Dickey; Gordon Y C Cheung; Michael Otto
Journal:  Nat Rev Drug Discov       Date:  2017-03-24       Impact factor: 84.694

5.  Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.

Authors:  Toby Passioura; Hiroki Sato; Katsuya Sakai; Kenichiro Ito; Hiroki Furuhashi; Masataka Umitsu; Junichi Takagi; Yukinari Kato; Hidefumi Mukai; Shota Warashina; Maki Zouda; Yasuyoshi Watanabe; Seiji Yano; Mikihiro Shibata; Hiroaki Suga; Kunio Matsumoto
Journal:  Nat Chem Biol       Date:  2019-05-17       Impact factor: 15.040

6.  Simplified Autoinducing Peptide Mimetics with Single-Nanomolar Activity Against the Staphylococcus aureus AgrC Quorum Sensing Receptor.

Authors:  Joseph K Vasquez; Helen E Blackwell
Journal:  ACS Infect Dis       Date:  2019-03-13       Impact factor: 5.084

Review 7.  Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles.

Authors:  Boyuan Wang; Tom W Muir
Journal:  Cell Chem Biol       Date:  2016-02-18       Impact factor: 8.116

8.  Identification of a Molecular Latch that Regulates Staphylococcal Virulence.

Authors:  Qian Xie; Aishan Zhao; Philip D Jeffrey; Minyoung Kevin Kim; Bonnie L Bassler; Howard A Stone; Richard P Novick; Tom W Muir
Journal:  Cell Chem Biol       Date:  2019-02-14       Impact factor: 8.116

9.  ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap.

Authors:  Tauno Metsalu; Jaak Vilo
Journal:  Nucleic Acids Res       Date:  2015-05-12       Impact factor: 16.971

Review 10.  Recent advances in Staphylococcus aureus infection: focus on vaccine development.

Authors:  Shamshul Ansari; Rajesh Kumar Jha; Shyam Kumar Mishra; Birendra Raj Tiwari; Ahmed Morad Asaad
Journal:  Infect Drug Resist       Date:  2019-05-13       Impact factor: 4.003
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  7 in total

1.  Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis.

Authors:  Aishan Zhao; Steven P Bodine; Qian Xie; Boyuan Wang; Geeta Ram; Richard P Novick; Tom W Muir
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-08       Impact factor: 12.779

2.  Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay.

Authors:  Thomas J Polaske; Curran G Gahan; Kayleigh E Nyffeler; David M Lynn; Helen E Blackwell
Journal:  Cell Chem Biol       Date:  2021-12-20       Impact factor: 9.039

3.  In vitro-Constructed Ribosomes Enable Multi-site Incorporation of Noncanonical Amino Acids into Proteins.

Authors:  Yi Liu; Roderick G Davis; Paul M Thomas; Neil L Kelleher; Michael C Jewett
Journal:  Biochemistry       Date:  2021-01-11       Impact factor: 3.162

Review 4.  Targeting a highly conserved domain in bacterial histidine kinases to generate inhibitors with broad spectrum activity.

Authors:  Conrad A Fihn; Erin E Carlson
Journal:  Curr Opin Microbiol       Date:  2021-04-28       Impact factor: 7.584

5.  Comparative Metabolic Pathways Analysis and Subtractive Genomics Profiling to Prioritize Potential Drug Targets Against Streptococcus pneumoniae.

Authors:  Kanwal Khan; Khurshid Jalal; Ajmal Khan; Ahmed Al-Harrasi; Reaz Uddin
Journal:  Front Microbiol       Date:  2022-02-10       Impact factor: 5.640

Review 6.  Two-Component Systems of S. aureus: Signaling and Sensing Mechanisms.

Authors:  Lisa Bleul; Patrice Francois; Christiane Wolz
Journal:  Genes (Basel)       Date:  2021-12-23       Impact factor: 4.096

7. 

Authors:  Korbin H J West; Curran G Gahan; Patricia R Kierski; Diego F Calderon; Ke Zhao; Charles J Czuprynski; Jonathan F McAnulty; David M Lynn; Helen E Blackwell
Journal:  Angew Chem Int Ed Engl       Date:  2022-03-25       Impact factor: 16.823
  7 in total

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