Connie Svob1,2, Myrna M Weissman1,2,3. 1. Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. 2. Division of Translational Epidemiology, New York State Psychiatric Institute, New York, NY, USA. 3. Mailman School of Public Health, Columbia University, New York, NY, USA.
Abstract
BACKGROUND: About forty years ago we began a study of the offspring of depressed (high-risk) and not depressed (low-risk) parents, matched for age and gender, from the same community. We interviewed all of their biological children, blind to the clinical status of the parents. Over the years, we returned to re-interview the families at baseline, 2, 10, 20, 25 30, and 35 years. As the years went by and the sample grew up, we also interviewed the third generation, the grandchildren. As technology became available, we included measures of electrophysiology and magnetic resonance imaging in order to better understand the mechanisms of risk. At the 10-year follow up, we included measures of religion and spirituality - namely, personal religious/spiritual importance and frequency of religious service attendance. We included these measures in all subsequent waves including a more extensive follow up of religious beliefs at the 35-year follow up. ISSUES OF FOCUS: This paper describes the study design and highlights the key findings of the role of religious/spiritual belief in the transmission and endurance of depression using clinical and biological approaches. METHODS: We describe study findings based on clinical measures, as well as physiological measures that employed electrophysiology and magnetic resonance imaging. RESULTS: Taken together, the findings suggest that religiosity/spirituality is protective against depression in high-risk individuals at both clinical and physiological levels. IMPLICATIONS: The findings suggest religiosity interacts with both culture and biology in its impact on depression.
BACKGROUND: About forty years ago we began a study of the offspring of depressed (high-risk) and not depressed (low-risk) parents, matched for age and gender, from the same community. We interviewed all of their biological children, blind to the clinical status of the parents. Over the years, we returned to re-interview the families at baseline, 2, 10, 20, 25 30, and 35 years. As the years went by and the sample grew up, we also interviewed the third generation, the grandchildren. As technology became available, we included measures of electrophysiology and magnetic resonance imaging in order to better understand the mechanisms of risk. At the 10-year follow up, we included measures of religion and spirituality - namely, personal religious/spiritual importance and frequency of religious service attendance. We included these measures in all subsequent waves including a more extensive follow up of religious beliefs at the 35-year follow up. ISSUES OF FOCUS: This paper describes the study design and highlights the key findings of the role of religious/spiritual belief in the transmission and endurance of depression using clinical and biological approaches. METHODS: We describe study findings based on clinical measures, as well as physiological measures that employed electrophysiology and magnetic resonance imaging. RESULTS: Taken together, the findings suggest that religiosity/spirituality is protective against depression in high-risk individuals at both clinical and physiological levels. IMPLICATIONS: The findings suggest religiosity interacts with both culture and biology in its impact on depression.
Entities:
Keywords:
Clinical; Clinique; Longitudinal; Neurobiologie; Neurobiology; Religion / spiritualité; Religion/spirituality; Risk for depression; Risque de dépression
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