| Literature DB >> 32817469 |
Eric D Sun1, Thomas C T Michaels1, L Mahadevan2,3,4.
Abstract
Many complex systems experience damage accumulation, which leads to aging, manifest as an increasing probability of system collapse with time. This naturally raises the question of how to maximize health and longevity in an aging system at minimal cost of maintenance and intervention. Here, we pose this question in the context of a simple interdependent network model of aging in complex systems and show that it exhibits cascading failures. We then use both optimal control theory and reinforcement learning alongside a combination of analysis and simulation to determine optimal maintenance protocols. These protocols may motivate the rational design of strategies for promoting longevity in aging complex systems with potential applications in therapeutic schedules and engineered system maintenance.Keywords: aging; control; failure; networks; repair
Year: 2020 PMID: 32817469 PMCID: PMC7456090 DOI: 10.1073/pnas.2006375117
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205