Literature DB >> 32817469

Optimal control of aging in complex networks.

Eric D Sun1, Thomas C T Michaels1, L Mahadevan2,3,4.   

Abstract

Many complex systems experience damage accumulation, which leads to aging, manifest as an increasing probability of system collapse with time. This naturally raises the question of how to maximize health and longevity in an aging system at minimal cost of maintenance and intervention. Here, we pose this question in the context of a simple interdependent network model of aging in complex systems and show that it exhibits cascading failures. We then use both optimal control theory and reinforcement learning alongside a combination of analysis and simulation to determine optimal maintenance protocols. These protocols may motivate the rational design of strategies for promoting longevity in aging complex systems with potential applications in therapeutic schedules and engineered system maintenance.

Keywords:  aging; control; failure; networks; repair

Year:  2020        PMID: 32817469      PMCID: PMC7456090          DOI: 10.1073/pnas.2006375117

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


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