| Literature DB >> 32815931 |
Lei Wang1, Hidenori Okamura, Shigeki Sasaki, Yosuke Taniguchi.
Abstract
We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2'-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.Entities:
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Year: 2020 PMID： 32815931 DOI： 10.1039/d0cc04240d
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222