Rachel M Reeves1, Maarten van Wijhe2, Sabine Tong3, Toni Lehtonen4,5, Luca Stona6, Anne C Teirlinck7, Liliana Vazquez Fernandez8, You Li1, Carlo Giaquinto6, Thea Kølsen Fischer2,9, Clarisse Demont10, Terho Heikkinen11, Irene Speltra6, Michiel van Boven7, Håkon Bøås8, Harry Campbell1. 1. Centre for Global Health, University of Edinburgh, Edinburgh, United Kingdom. 2. Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark. 3. Sanofi, Chilly-Mazarin, France. 4. Finnish Institute for Health and Welfare, Helsinki, Finland. 5. Turku University Hospital, Turku, Finland. 6. Fondazione Penta, Padova, Italy. 7. Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands. 8. Department of Infectious Diseases, Epidemiology, and Modelling, Norwegian Institute of Public Health, Oslo, Norway. 9. Department of Clinical Research, Nordsjælland Hospital Hilleroed and University of Southern Denmark, Odense, Denmark. 10. Global Vaccine Epidemiology and Modelling Department, Sanofi Pasteur, Lyon, France. 11. Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
Abstract
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden. METHODS: We explored routinely collected hospital data on RSV in children aged < 5 years in 7 European countries. We compare RSV-associated admission rates, age, seasonality, and time trends between countries. RESULTS: We found similar age distributions of RSV-associated hospital admissions in each country, with the highest burden in children < 1 years old and peak at age 1 month. Average annual rates of RTI admission were 41.3-112.0 per 1000 children aged < 1 year and 8.6-22.3 per 1000 children aged < 1 year. In children aged < 5 years, 57%-72% of RTI admissions with specified causal pathogen were coded as RSV, with 62%-87% of pathogen-coded admissions in children < 1 year coded as RSV. CONCLUSIONS: Our results demonstrate the benefits and limitations of using linked routinely collected data to explore epidemiology and burden of RSV. Our future work will use these data to generate estimates of RSV burden using time-series modelling methodology, to inform policymaking and regulatory decisions regarding RSV immunization strategy and monitor the impact of future vaccines.
BACKGROUND:Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden. METHODS: We explored routinely collected hospital data on RSV in children aged < 5 years in 7 European countries. We compare RSV-associated admission rates, age, seasonality, and time trends between countries. RESULTS: We found similar age distributions of RSV-associated hospital admissions in each country, with the highest burden in children < 1 years old and peak at age 1 month. Average annual rates of RTI admission were 41.3-112.0 per 1000 children aged < 1 year and 8.6-22.3 per 1000 children aged < 1 year. In children aged < 5 years, 57%-72% of RTI admissions with specified causal pathogen were coded as RSV, with 62%-87% of pathogen-coded admissions in children < 1 year coded as RSV. CONCLUSIONS: Our results demonstrate the benefits and limitations of using linked routinely collected data to explore epidemiology and burden of RSV. Our future work will use these data to generate estimates of RSV burden using time-series modelling methodology, to inform policymaking and regulatory decisions regarding RSV immunization strategy and monitor the impact of future vaccines.
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