| Literature DB >> 32815424 |
Rachael A Muck1,2, Hans P A Van Dongen1,2, Michelle A Schmidt1,2, Jonathan P Wisor1,2, Matthew E Layton1,2, Dawn M DePriest1,3, Kimberly A Honn1,2, Brieann C Satterfield1,2.
Abstract
Total sleep deprivation (TSD) and time-on-task (TOT), especially in combination, increase cognitive instability and cause performance impairment. There are large inter-individual differences in TSD and TOT effects which, in part, have a genetic basis. Here, we show that the dopamine receptor D2 C957T genetic polymorphism predicts the magnitude of the TOT effect on a psychomotor vigilance test (PVT) during 38 h of TSD. This finding indicates that dopamine availability in the striatum, where the dopamine receptor D2 is most prevalent, influences the TOT effect, suggesting a role for dopaminergic pathways in sustained attention deficits during sleep loss.Entities:
Keywords: Sustained attention; cognitive impairment; dopamine; psychomotor vigilance test (PVT); single nucleotide polymorphism; sleep loss; striatum
Mesh：
Substances：
Year: 2020 PMID： 32815424 DOI： 10.1080/07420528.2020.1804925
Source DB: PubMed Journal: Chronobiol Int ISSN： 0742-0528 Impact factor: 2.877