Evangelos Kogias1,2, Thomas Bast2,3, Susanne Schubert-Bast4,5,6, Gert Wiegand7, Armin Brandt8, Karl Strobl2, Rudolf Korinthenberg9, Andreas Schulze-Bonhage8, Josef Zentner1, Georgia Ramantani2,8,10. 1. Department of Neurosurgery, University Hospital Freiburg, Freiburg im Breisgau, Germany. 2. Medical Faculty, University of Freiburg, Freiburg im Breisgau, Germany. 3. Epilepsy Center Kork, Kehl-Kork, Germany. 4. Department of General Pediatrics, University Children's Hospital Heidelberg, Heidelberg, Germany. 5. Department of Neuropediatrics, University Children's Hospital Frankfurt, Frankfurt, Germany. 6. Epilepsy Center Frankfurt Rhine-Main, Frankfurt am Main, Germany. 7. Department of Neuropediatrics, University Medical Center Schleswig-Holstein, Kiel, Germany. 8. Epilepsy Center, University Hospital Freiburg, Freiburg im Breisgau, Germany. 9. Department of Neuropediatrics and Muscular Disorders, University Children's Hospital Freiburg, Freiburg im Breisgau, Germany. 10. Department of Neuropediatrics, University Children's Hospital Zurich, Zurich, Switzerland.
Abstract
BACKGROUND: Although multilobar resections correspond to one-fifth of pediatric epilepsy surgery, there are little data on long-term seizure control. OBJECTIVE: To investigate the long-term seizure outcomes of children and adolescents undergoing multilobar epilepsy surgery and identify their predictors. METHODS: In this retrospective study, we considered 69 consecutive patients that underwent multilobar epilepsy surgery at the age of 10.0 ± 5.0 yr (mean ± SD). The magnetic resonance imaging revealed a lesion in all but 2 cases. Resections were temporo-parieto(-occipital) in 30%, temporo-occipital in 41%, parieto-occipital in 16%, and fronto-(temporo)-parietal in 13% cases. Etiologies were determined as focal cortical dysplasia in 67%, perinatal or postnatal ischemic lesions in 23%, and benign tumors in 10% of cases. RESULTS: At last follow-up of median 9 yr (range 2.8-14.8), 48% patients were seizure free; 33% were off antiepileptic drugs. 10% of patients, all with dysplastic etiology, required reoperations: 4 of 7 achieved seizure freedom. Seizure recurrence occurred mostly (80%) within the first 6 mo. Among presurgical variables, only an epileptogenic zone far from eloquent cortex independently correlated with significantly higher rates of seizure arrest in multivariate analysis. Among postsurgical variables, the absence of residual lesion and of acute postsurgical seizures was independently associated with significantly higher rates of seizure freedom. CONCLUSION: Our study demonstrates that multilobar epilepsy surgery is effective regarding long-term seizure freedom and antiepileptic drug withdrawal in selected pediatric candidates. Epileptogenic zones-and lesions-localized distant from eloquent cortex and, thus, fully resectable predispose for seizure control. Acute postsurgical seizures are critical markers of seizure recurrence that should lead to prompt reevaluation.
BACKGROUND: Although multilobar resections correspond to one-fifth of pediatric epilepsy surgery, there are little data on long-term seizure control. OBJECTIVE: To investigate the long-term seizure outcomes of children and adolescents undergoing multilobar epilepsy surgery and identify their predictors. METHODS: In this retrospective study, we considered 69 consecutive patients that underwent multilobar epilepsy surgery at the age of 10.0 ± 5.0 yr (mean ± SD). The magnetic resonance imaging revealed a lesion in all but 2 cases. Resections were temporo-parieto(-occipital) in 30%, temporo-occipital in 41%, parieto-occipital in 16%, and fronto-(temporo)-parietal in 13% cases. Etiologies were determined as focal cortical dysplasia in 67%, perinatal or postnatal ischemic lesions in 23%, and benign tumors in 10% of cases. RESULTS: At last follow-up of median 9 yr (range 2.8-14.8), 48% patients were seizure free; 33% were off antiepileptic drugs. 10% of patients, all with dysplastic etiology, required reoperations: 4 of 7 achieved seizure freedom. Seizure recurrence occurred mostly (80%) within the first 6 mo. Among presurgical variables, only an epileptogenic zone far from eloquent cortex independently correlated with significantly higher rates of seizure arrest in multivariate analysis. Among postsurgical variables, the absence of residual lesion and of acute postsurgical seizures was independently associated with significantly higher rates of seizure freedom. CONCLUSION: Our study demonstrates that multilobar epilepsy surgery is effective regarding long-term seizure freedom and antiepileptic drug withdrawal in selected pediatric candidates. Epileptogenic zones-and lesions-localized distant from eloquent cortex and, thus, fully resectable predispose for seizure control. Acute postsurgical seizures are critical markers of seizure recurrence that should lead to prompt reevaluation.
Authors: Dorottya Cserpan; Antonio Gennari; Luca Gaito; Santo Pietro Lo Biundo; Ruth Tuura; Johannes Sarnthein; Georgia Ramantani Journal: Epilepsia Open Date: 2022-05-06